A second DNA binding site in human BRCA2 promotes homologous recombination

BRCA2 tumour-suppressor protein is well known for its role in DNA repair by homologous recombination (HR); assisting the loading of RAD51 recombinase at DNA double-strand breaks. This function is executed by the C-terminal DNA binding domain (CTD) which binds single-stranded (ss)DNA, and the BRC rep...

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Detalles Bibliográficos
Autores principales: von Nicolai, Catharina, Ehlén, Åsa, Martin, Charlotte, Zhang, Xiaodong, Carreira, Aura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027613/
https://www.ncbi.nlm.nih.gov/pubmed/27628236
http://dx.doi.org/10.1038/ncomms12813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027613/
https://www.ncbi.nlm.nih.gov/pubmed/27628236
http://dx.doi.org/10.1038/ncomms12813

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