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A second DNA binding site in human BRCA2 promotes homologous recombination

BRCA2 tumour-suppressor protein is well known for its role in DNA repair by homologous recombination (HR); assisting the loading of RAD51 recombinase at DNA double-strand breaks. This function is executed by the C-terminal DNA binding domain (CTD) which binds single-stranded (ss)DNA, and the BRC rep...

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Detalles Bibliográficos
Autores principales:	von Nicolai, Catharina, Ehlén, Åsa, Martin, Charlotte, Zhang, Xiaodong, Carreira, Aura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027613/ https://www.ncbi.nlm.nih.gov/pubmed/27628236 http://dx.doi.org/10.1038/ncomms12813

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