Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases

The risk of tumorigenicity is a hurdle for regenerative medicine using induced pluripotent stem cells (iPSCs). Although teratoma formation is readily distinguishable, the malignant transformation of iPSC derivatives has not been clearly defined due to insufficient analysis of histology and phenotype...

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Detalles Bibliográficos
Autores principales: Sugai, Keiko, Fukuzawa, Ryuji, Shofuda, Tomoko, Fukusumi, Hayato, Kawabata, Soya, Nishiyama, Yuichiro, Higuchi, Yuichiro, Kawai, Kenji, Isoda, Miho, Kanematsu, Daisuke, Hashimoto-Tamaoki, Tomoko, Kohyama, Jun, Iwanami, Akio, Suemizu, Hiroshi, Ikeda, Eiji, Matsumoto, Morio, Kanemura, Yonehiro, Nakamura, Masaya, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027634/
https://www.ncbi.nlm.nih.gov/pubmed/27642008
http://dx.doi.org/10.1186/s13041-016-0265-8

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