Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by va...

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Detalles Bibliográficos
Autores principales: Agrawal, Anurodh Shankar, Tao, Xinrong, Algaissi, Abdullah, Garron, Tania, Narayanan, Krishna, Peng, Bi-Hung, Couch, Robert B., Tseng, Chien-Te K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027702/
https://www.ncbi.nlm.nih.gov/pubmed/27269431
http://dx.doi.org/10.1080/21645515.2016.1177688

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