Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity

Trypanosoma cruzi infection is controlled but not eliminated by host immunity. The T. cruzi trans-sialidase (TS) gene superfamily encodes immunodominant protective antigens, but expression of altered peptide ligands by different TS genes has been hypothesized to promote immunoevasion. We molecularly...

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Detalles Bibliográficos
Autores principales: Eickhoff, Christopher S., Zhang, Xiuli, Vasconcelos, Jose R., Motz, R. Geoffrey, Sullivan, Nicole L., O’Shea, Kelly, Pozzi, Nicola, Gohara, David W., Blase, Jennifer R., Di Cera, Enrico, Hoft, Daniel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028030/
https://www.ncbi.nlm.nih.gov/pubmed/27642757
http://dx.doi.org/10.1371/journal.ppat.1005896

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