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Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model

[Image: see text] Whole brain radiotherapy (WBRT) produces unwanted sequelae, albeit via unknown mechanisms. A deacetylase expressed in the central nervous system, Sirtuin 2 (SIRT2), has been linked to neurodegeneration. Therefore, we sought to challenge the notion that a single disease pathway is r...

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Detalles Bibliográficos
Autores principales:	Shukla, Sudhanshu, Shankavaram, Uma T., Nguyen, Phuongmai, Stanley, Bruce A., Smart, DeeDee K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028131/ https://www.ncbi.nlm.nih.gov/pubmed/26373435 http://dx.doi.org/10.1021/acs.jproteome.5b00083

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