The role of NMDAR antibody in the etiopathogenesis of schizophrenia

Many authors have reported the presence of serum NMDAR antibodies in varying proportions of patients with schizophrenia; however, many others have not been able to confirm this. Because of the contradictory findings reported in various studies, more definitive research on this issue is required. Hen...

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Autores principales: Timucin, Damla, Ozdemir, Osman, Parlak, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028168/
https://www.ncbi.nlm.nih.gov/pubmed/27695333
http://dx.doi.org/10.2147/NDT.S113872
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author Timucin, Damla
Ozdemir, Osman
Parlak, Mehmet
author_facet Timucin, Damla
Ozdemir, Osman
Parlak, Mehmet
author_sort Timucin, Damla
collection PubMed
description Many authors have reported the presence of serum NMDAR antibodies in varying proportions of patients with schizophrenia; however, many others have not been able to confirm this. Because of the contradictory findings reported in various studies, more definitive research on this issue is required. Hence, we have investigated the NR1 subunit of NMDAR antibodies in patients with schizophrenia (n=49) and healthy controls (n=48). None of the investigated patients with schizophrenia and none of the healthy controls showed positive antibody against the NR1 subunit of the NMDAR. On the basis of this result, we conclude that the NR1 subunit of the NMDAR antibodies does not seem to have a role in schizophrenia.
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spelling pubmed-50281682016-09-30 The role of NMDAR antibody in the etiopathogenesis of schizophrenia Timucin, Damla Ozdemir, Osman Parlak, Mehmet Neuropsychiatr Dis Treat Original Research Many authors have reported the presence of serum NMDAR antibodies in varying proportions of patients with schizophrenia; however, many others have not been able to confirm this. Because of the contradictory findings reported in various studies, more definitive research on this issue is required. Hence, we have investigated the NR1 subunit of NMDAR antibodies in patients with schizophrenia (n=49) and healthy controls (n=48). None of the investigated patients with schizophrenia and none of the healthy controls showed positive antibody against the NR1 subunit of the NMDAR. On the basis of this result, we conclude that the NR1 subunit of the NMDAR antibodies does not seem to have a role in schizophrenia. Dove Medical Press 2016-09-13 /pmc/articles/PMC5028168/ /pubmed/27695333 http://dx.doi.org/10.2147/NDT.S113872 Text en © 2016 Timucin et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Timucin, Damla
Ozdemir, Osman
Parlak, Mehmet
The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_full The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_fullStr The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_full_unstemmed The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_short The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_sort role of nmdar antibody in the etiopathogenesis of schizophrenia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028168/
https://www.ncbi.nlm.nih.gov/pubmed/27695333
http://dx.doi.org/10.2147/NDT.S113872
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