Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8(+) T-c...

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Detalles Bibliográficos
Autores principales: Joosten, Simone A., Sullivan, Lucy C., Ottenhoff, Tom H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028793/
https://www.ncbi.nlm.nih.gov/pubmed/27699181
http://dx.doi.org/10.1155/2016/2695396
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author Joosten, Simone A.
Sullivan, Lucy C.
Ottenhoff, Tom H. M.
author_facet Joosten, Simone A.
Sullivan, Lucy C.
Ottenhoff, Tom H. M.
author_sort Joosten, Simone A.
collection PubMed
description Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8(+) T-cells are an interesting new player in the field of immunology. Future work should address their exact roles and relative contributions in the immune response against infectious diseases.
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spelling pubmed-50287932016-10-03 Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases Joosten, Simone A. Sullivan, Lucy C. Ottenhoff, Tom H. M. J Immunol Res Review Article Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8(+) T-cells are an interesting new player in the field of immunology. Future work should address their exact roles and relative contributions in the immune response against infectious diseases. Hindawi Publishing Corporation 2016 2016-09-06 /pmc/articles/PMC5028793/ /pubmed/27699181 http://dx.doi.org/10.1155/2016/2695396 Text en Copyright © 2016 Simone A. Joosten et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Joosten, Simone A.
Sullivan, Lucy C.
Ottenhoff, Tom H. M.
Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases
title Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases
title_full Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases
title_fullStr Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases
title_full_unstemmed Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases
title_short Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases
title_sort characteristics of hla-e restricted t-cell responses and their role in infectious diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028793/
https://www.ncbi.nlm.nih.gov/pubmed/27699181
http://dx.doi.org/10.1155/2016/2695396
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