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Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer
Gastrointestinal cancer has been one of the five most commonly diagnosed and leading causes of cancer mortality over the past few decades. Great progress in traditional therapies has been made, which prolonged survival in patients with early cancer, yet tumor relapse and drug resistance still occurr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028813/ https://www.ncbi.nlm.nih.gov/pubmed/27672294 http://dx.doi.org/10.3748/wjg.v22.i35.7999 |
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author | Huang, Fang Wang, Bin-Rong Wu, Ye-Qing Wang, Fan-Chao Zhang, Jian Wang, Yi-Gang |
author_facet | Huang, Fang Wang, Bin-Rong Wu, Ye-Qing Wang, Fan-Chao Zhang, Jian Wang, Yi-Gang |
author_sort | Huang, Fang |
collection | PubMed |
description | Gastrointestinal cancer has been one of the five most commonly diagnosed and leading causes of cancer mortality over the past few decades. Great progress in traditional therapies has been made, which prolonged survival in patients with early cancer, yet tumor relapse and drug resistance still occurred, which is explained by the cancer stem cell (CSC) theory. Oncolytic virotherapy has attracted increasing interest in cancer because of its ability to infect and lyse CSCs. This paper reviews the basic knowledge, CSC markers and therapeutics of gastrointestinal cancer (liver, gastric, colon and pancreatic cancer), as well as research advances and possible molecular mechanisms of various oncolytic viruses against gastrointestinal CSCs. This paper also summarizes the existing obstacles to oncolytic virotherapy and proposes several alternative suggestions to overcome the therapeutic limitations. |
format | Online Article Text |
id | pubmed-5028813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-50288132016-09-27 Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer Huang, Fang Wang, Bin-Rong Wu, Ye-Qing Wang, Fan-Chao Zhang, Jian Wang, Yi-Gang World J Gastroenterol Review Gastrointestinal cancer has been one of the five most commonly diagnosed and leading causes of cancer mortality over the past few decades. Great progress in traditional therapies has been made, which prolonged survival in patients with early cancer, yet tumor relapse and drug resistance still occurred, which is explained by the cancer stem cell (CSC) theory. Oncolytic virotherapy has attracted increasing interest in cancer because of its ability to infect and lyse CSCs. This paper reviews the basic knowledge, CSC markers and therapeutics of gastrointestinal cancer (liver, gastric, colon and pancreatic cancer), as well as research advances and possible molecular mechanisms of various oncolytic viruses against gastrointestinal CSCs. This paper also summarizes the existing obstacles to oncolytic virotherapy and proposes several alternative suggestions to overcome the therapeutic limitations. Baishideng Publishing Group Inc 2016-09-21 2016-09-21 /pmc/articles/PMC5028813/ /pubmed/27672294 http://dx.doi.org/10.3748/wjg.v22.i35.7999 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Huang, Fang Wang, Bin-Rong Wu, Ye-Qing Wang, Fan-Chao Zhang, Jian Wang, Yi-Gang Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer |
title | Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer |
title_full | Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer |
title_fullStr | Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer |
title_full_unstemmed | Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer |
title_short | Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer |
title_sort | oncolytic viruses against cancer stem cells: a promising approach for gastrointestinal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028813/ https://www.ncbi.nlm.nih.gov/pubmed/27672294 http://dx.doi.org/10.3748/wjg.v22.i35.7999 |
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