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Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer

Gastrointestinal cancer has been one of the five most commonly diagnosed and leading causes of cancer mortality over the past few decades. Great progress in traditional therapies has been made, which prolonged survival in patients with early cancer, yet tumor relapse and drug resistance still occurr...

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Autores principales: Huang, Fang, Wang, Bin-Rong, Wu, Ye-Qing, Wang, Fan-Chao, Zhang, Jian, Wang, Yi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028813/
https://www.ncbi.nlm.nih.gov/pubmed/27672294
http://dx.doi.org/10.3748/wjg.v22.i35.7999
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author Huang, Fang
Wang, Bin-Rong
Wu, Ye-Qing
Wang, Fan-Chao
Zhang, Jian
Wang, Yi-Gang
author_facet Huang, Fang
Wang, Bin-Rong
Wu, Ye-Qing
Wang, Fan-Chao
Zhang, Jian
Wang, Yi-Gang
author_sort Huang, Fang
collection PubMed
description Gastrointestinal cancer has been one of the five most commonly diagnosed and leading causes of cancer mortality over the past few decades. Great progress in traditional therapies has been made, which prolonged survival in patients with early cancer, yet tumor relapse and drug resistance still occurred, which is explained by the cancer stem cell (CSC) theory. Oncolytic virotherapy has attracted increasing interest in cancer because of its ability to infect and lyse CSCs. This paper reviews the basic knowledge, CSC markers and therapeutics of gastrointestinal cancer (liver, gastric, colon and pancreatic cancer), as well as research advances and possible molecular mechanisms of various oncolytic viruses against gastrointestinal CSCs. This paper also summarizes the existing obstacles to oncolytic virotherapy and proposes several alternative suggestions to overcome the therapeutic limitations.
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spelling pubmed-50288132016-09-27 Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer Huang, Fang Wang, Bin-Rong Wu, Ye-Qing Wang, Fan-Chao Zhang, Jian Wang, Yi-Gang World J Gastroenterol Review Gastrointestinal cancer has been one of the five most commonly diagnosed and leading causes of cancer mortality over the past few decades. Great progress in traditional therapies has been made, which prolonged survival in patients with early cancer, yet tumor relapse and drug resistance still occurred, which is explained by the cancer stem cell (CSC) theory. Oncolytic virotherapy has attracted increasing interest in cancer because of its ability to infect and lyse CSCs. This paper reviews the basic knowledge, CSC markers and therapeutics of gastrointestinal cancer (liver, gastric, colon and pancreatic cancer), as well as research advances and possible molecular mechanisms of various oncolytic viruses against gastrointestinal CSCs. This paper also summarizes the existing obstacles to oncolytic virotherapy and proposes several alternative suggestions to overcome the therapeutic limitations. Baishideng Publishing Group Inc 2016-09-21 2016-09-21 /pmc/articles/PMC5028813/ /pubmed/27672294 http://dx.doi.org/10.3748/wjg.v22.i35.7999 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Huang, Fang
Wang, Bin-Rong
Wu, Ye-Qing
Wang, Fan-Chao
Zhang, Jian
Wang, Yi-Gang
Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer
title Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer
title_full Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer
title_fullStr Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer
title_full_unstemmed Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer
title_short Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer
title_sort oncolytic viruses against cancer stem cells: a promising approach for gastrointestinal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028813/
https://www.ncbi.nlm.nih.gov/pubmed/27672294
http://dx.doi.org/10.3748/wjg.v22.i35.7999
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