Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection

A patient with severe lupus nephritis developed thrombocytopenia during treatment with high-dose steroids. In addition to viral- or disease-induced cytopenia, the pathology was believed to arise from diverse contributing factors, such as thrombotic microangiopathy and heparin-related thrombocytopeni...

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Autores principales: Suzuki, Satoshi, Nakajima, Shihoko, Ando, Taiki, Oda, Keisuke, Sugita, Manabu, Maeda, Kunimi, Nakiri, Yutaka, Takasaki, Yoshinari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028856/
https://www.ncbi.nlm.nih.gov/pubmed/27699076
http://dx.doi.org/10.1155/2016/6571621
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author Suzuki, Satoshi
Nakajima, Shihoko
Ando, Taiki
Oda, Keisuke
Sugita, Manabu
Maeda, Kunimi
Nakiri, Yutaka
Takasaki, Yoshinari
author_facet Suzuki, Satoshi
Nakajima, Shihoko
Ando, Taiki
Oda, Keisuke
Sugita, Manabu
Maeda, Kunimi
Nakiri, Yutaka
Takasaki, Yoshinari
author_sort Suzuki, Satoshi
collection PubMed
description A patient with severe lupus nephritis developed thrombocytopenia during treatment with high-dose steroids. In addition to viral- or disease-induced cytopenia, the pathology was believed to arise from diverse contributing factors, such as thrombotic microangiopathy and heparin-related thrombocytopenia (HIT). By combining plasma exchange therapy and intravenous cyclophosphamide, we successfully controlled the SLE activity and improved the thrombocytopenia. An antecedent bacterial infection or SLE activity is believed to have contributed to the concurrent HIT.
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spelling pubmed-50288562016-10-03 Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection Suzuki, Satoshi Nakajima, Shihoko Ando, Taiki Oda, Keisuke Sugita, Manabu Maeda, Kunimi Nakiri, Yutaka Takasaki, Yoshinari Case Rep Rheumatol Case Report A patient with severe lupus nephritis developed thrombocytopenia during treatment with high-dose steroids. In addition to viral- or disease-induced cytopenia, the pathology was believed to arise from diverse contributing factors, such as thrombotic microangiopathy and heparin-related thrombocytopenia (HIT). By combining plasma exchange therapy and intravenous cyclophosphamide, we successfully controlled the SLE activity and improved the thrombocytopenia. An antecedent bacterial infection or SLE activity is believed to have contributed to the concurrent HIT. Hindawi Publishing Corporation 2016 2016-09-06 /pmc/articles/PMC5028856/ /pubmed/27699076 http://dx.doi.org/10.1155/2016/6571621 Text en Copyright © 2016 Satoshi Suzuki et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Suzuki, Satoshi
Nakajima, Shihoko
Ando, Taiki
Oda, Keisuke
Sugita, Manabu
Maeda, Kunimi
Nakiri, Yutaka
Takasaki, Yoshinari
Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection
title Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection
title_full Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection
title_fullStr Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection
title_full_unstemmed Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection
title_short Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection
title_sort heparin-related thrombocytopenia triggered by severe status of systemic lupus erythematosus and bacterial infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028856/
https://www.ncbi.nlm.nih.gov/pubmed/27699076
http://dx.doi.org/10.1155/2016/6571621
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