Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects

Aims: We investigated whether radiation-induced nontargeted effects are involved in the cytotoxic effects of anticell surface monoclonal antibodies labeled with Auger electron emitters, such as iodine 125 (monoclonal antibodies labeled with (125)I [(125)I-mAbs]). Results: We showed that the cytotoxi...

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Detalles Bibliográficos
Autores principales: Paillas, Salomé, Ladjohounlou, Riad, Lozza, Catherine, Pichard, Alexandre, Boudousq, Vincent, Jarlier, Marta, Sevestre, Samuel, Le Blay, Marion, Deshayes, Emmanuel, Sosabowski, Jane, Chardès, Thierry, Navarro-Teulon, Isabelle, Mairs, Robert J., Pouget, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Original Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028911/
https://www.ncbi.nlm.nih.gov/pubmed/27224059
http://dx.doi.org/10.1089/ars.2015.6309

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