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Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report
BACKGROUND: Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Chronic cutaneous lupus erythematosus (CCLE) is an autoimmune disease that is associated with autoantibody production and T-cell dysfunction. Cutaneous manifestations of sarcoidosis may mimic CCLE and vice versa maki...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028922/ https://www.ncbi.nlm.nih.gov/pubmed/27646659 http://dx.doi.org/10.1186/s12895-016-0052-3 |
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author | Vatanchi, Marjon Sobhani, Kaivon Fisher, Valerie T. Meffert, Jeffrey J. |
author_facet | Vatanchi, Marjon Sobhani, Kaivon Fisher, Valerie T. Meffert, Jeffrey J. |
author_sort | Vatanchi, Marjon |
collection | PubMed |
description | BACKGROUND: Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Chronic cutaneous lupus erythematosus (CCLE) is an autoimmune disease that is associated with autoantibody production and T-cell dysfunction. Cutaneous manifestations of sarcoidosis may mimic CCLE and vice versa making it difficult to reach a diagnosis clinically. CASE PRESENTATION: We present a case of a 57-year-old woman with long-standing sarcoidosis who presented to clinic with diffuse painful plaques that were very distinct and suggestive of CCLE. She had a family history of both sarcoidosis and CCLE. The patient was immediately started on topical corticosteroids and oral hydroxychloroquine. Skin biopsy and the absence of direct immunofluorescence confirmed a skin manifestation of her previously diagnosed sarcoidosis, despite the clinical morphology favoring classic CCLE. CONCLUSION: Sarcoidosis may have diverse manifestations and may mimic other disease processes. A detailed history along with a low threshold for biopsy is important for determining a diagnosis. |
format | Online Article Text |
id | pubmed-5028922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50289222016-09-22 Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report Vatanchi, Marjon Sobhani, Kaivon Fisher, Valerie T. Meffert, Jeffrey J. BMC Dermatol Case Report BACKGROUND: Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Chronic cutaneous lupus erythematosus (CCLE) is an autoimmune disease that is associated with autoantibody production and T-cell dysfunction. Cutaneous manifestations of sarcoidosis may mimic CCLE and vice versa making it difficult to reach a diagnosis clinically. CASE PRESENTATION: We present a case of a 57-year-old woman with long-standing sarcoidosis who presented to clinic with diffuse painful plaques that were very distinct and suggestive of CCLE. She had a family history of both sarcoidosis and CCLE. The patient was immediately started on topical corticosteroids and oral hydroxychloroquine. Skin biopsy and the absence of direct immunofluorescence confirmed a skin manifestation of her previously diagnosed sarcoidosis, despite the clinical morphology favoring classic CCLE. CONCLUSION: Sarcoidosis may have diverse manifestations and may mimic other disease processes. A detailed history along with a low threshold for biopsy is important for determining a diagnosis. BioMed Central 2016-09-20 /pmc/articles/PMC5028922/ /pubmed/27646659 http://dx.doi.org/10.1186/s12895-016-0052-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Vatanchi, Marjon Sobhani, Kaivon Fisher, Valerie T. Meffert, Jeffrey J. Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report |
title | Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report |
title_full | Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report |
title_fullStr | Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report |
title_full_unstemmed | Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report |
title_short | Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report |
title_sort | cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028922/ https://www.ncbi.nlm.nih.gov/pubmed/27646659 http://dx.doi.org/10.1186/s12895-016-0052-3 |
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