Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply

BACKGROUND: To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)]. METHODS: After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent...

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Autores principales: Xu, Linfeng, Qiu, Xuefeng, Zhang, Yanting, Cao, Kai, Zhao, Xiaozhi, Wu, Jinhui, Hu, Yiqiao, Guo, Hongqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028944/
https://www.ncbi.nlm.nih.gov/pubmed/27646172
http://dx.doi.org/10.1186/s12967-016-1033-3
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author Xu, Linfeng
Qiu, Xuefeng
Zhang, Yanting
Cao, Kai
Zhao, Xiaozhi
Wu, Jinhui
Hu, Yiqiao
Guo, Hongqian
author_facet Xu, Linfeng
Qiu, Xuefeng
Zhang, Yanting
Cao, Kai
Zhao, Xiaozhi
Wu, Jinhui
Hu, Yiqiao
Guo, Hongqian
author_sort Xu, Linfeng
collection PubMed
description BACKGROUND: To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)]. METHODS: After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent accumulation in tumor 24 h post injection. X-ray was delivered to the tumor site 24 h after the injection of lip(PFH) under room air. The experimental mice were randomized into four groups: control (saline), lip(PFH) (lip(PFH) only), X-ray (X-ray only), and lip(PFH) + X-ray (lip(PFH) with X-ray radiation). Tumor volume and histology were monitored to assess treatment efficacy. RESULTS: Tumor growth was significantly reduced in mice received lip(PFH) and X-ray compared with X-ray only. The histological data also revealed more destruction of tumor tissue in lip(PFH) + X-ray group compared with X-ray only. In addition, lip(PFH) did not show any significant tissue damage to major organs or induce significant liver/kidney dysfunction. CONCLUSIONS: Lip(PFH) could accumulate in the tumor site and enhance radiotherapy without additional oxygen supply.
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spelling pubmed-50289442016-09-22 Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply Xu, Linfeng Qiu, Xuefeng Zhang, Yanting Cao, Kai Zhao, Xiaozhi Wu, Jinhui Hu, Yiqiao Guo, Hongqian J Transl Med Research BACKGROUND: To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)]. METHODS: After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent accumulation in tumor 24 h post injection. X-ray was delivered to the tumor site 24 h after the injection of lip(PFH) under room air. The experimental mice were randomized into four groups: control (saline), lip(PFH) (lip(PFH) only), X-ray (X-ray only), and lip(PFH) + X-ray (lip(PFH) with X-ray radiation). Tumor volume and histology were monitored to assess treatment efficacy. RESULTS: Tumor growth was significantly reduced in mice received lip(PFH) and X-ray compared with X-ray only. The histological data also revealed more destruction of tumor tissue in lip(PFH) + X-ray group compared with X-ray only. In addition, lip(PFH) did not show any significant tissue damage to major organs or induce significant liver/kidney dysfunction. CONCLUSIONS: Lip(PFH) could accumulate in the tumor site and enhance radiotherapy without additional oxygen supply. BioMed Central 2016-09-20 /pmc/articles/PMC5028944/ /pubmed/27646172 http://dx.doi.org/10.1186/s12967-016-1033-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Xu, Linfeng
Qiu, Xuefeng
Zhang, Yanting
Cao, Kai
Zhao, Xiaozhi
Wu, Jinhui
Hu, Yiqiao
Guo, Hongqian
Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
title Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
title_full Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
title_fullStr Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
title_full_unstemmed Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
title_short Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
title_sort liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028944/
https://www.ncbi.nlm.nih.gov/pubmed/27646172
http://dx.doi.org/10.1186/s12967-016-1033-3
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