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Current clinical trials testing the combination of immunotherapy with radiotherapy

Increasing evidence demonstrates that radiation acts as an immune stimulus, recruiting immune mediators that enable anti-tumor responses within and outside the radiation field. There has been a rapid expansion in the number of clinical trials harnessing radiation to enhance antitumor immunity. If po...

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Detalles Bibliográficos
Autores principales: Kang, Josephine, Demaria, Sandra, Formenti, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028964/
https://www.ncbi.nlm.nih.gov/pubmed/27660705
http://dx.doi.org/10.1186/s40425-016-0156-7
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author Kang, Josephine
Demaria, Sandra
Formenti, Silvia
author_facet Kang, Josephine
Demaria, Sandra
Formenti, Silvia
author_sort Kang, Josephine
collection PubMed
description Increasing evidence demonstrates that radiation acts as an immune stimulus, recruiting immune mediators that enable anti-tumor responses within and outside the radiation field. There has been a rapid expansion in the number of clinical trials harnessing radiation to enhance antitumor immunity. If positive, results of these trials will lead to a paradigm shift in the use of radiotherapy. In this review, we discuss the rationale for trials combining radiation with various immunotherapies, provide an update of recent clinical trial results and highlight trials currently in progress. We also address issues pertaining to the optimal incorporation of immunotherapy with radiation, including sequencing of treatment, radiation dosing and evaluation of clinical trial endpoints.
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spelling pubmed-50289642016-09-22 Current clinical trials testing the combination of immunotherapy with radiotherapy Kang, Josephine Demaria, Sandra Formenti, Silvia J Immunother Cancer Clinical Trials Monitor Increasing evidence demonstrates that radiation acts as an immune stimulus, recruiting immune mediators that enable anti-tumor responses within and outside the radiation field. There has been a rapid expansion in the number of clinical trials harnessing radiation to enhance antitumor immunity. If positive, results of these trials will lead to a paradigm shift in the use of radiotherapy. In this review, we discuss the rationale for trials combining radiation with various immunotherapies, provide an update of recent clinical trial results and highlight trials currently in progress. We also address issues pertaining to the optimal incorporation of immunotherapy with radiation, including sequencing of treatment, radiation dosing and evaluation of clinical trial endpoints. BioMed Central 2016-09-20 /pmc/articles/PMC5028964/ /pubmed/27660705 http://dx.doi.org/10.1186/s40425-016-0156-7 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Clinical Trials Monitor
Kang, Josephine
Demaria, Sandra
Formenti, Silvia
Current clinical trials testing the combination of immunotherapy with radiotherapy
title Current clinical trials testing the combination of immunotherapy with radiotherapy
title_full Current clinical trials testing the combination of immunotherapy with radiotherapy
title_fullStr Current clinical trials testing the combination of immunotherapy with radiotherapy
title_full_unstemmed Current clinical trials testing the combination of immunotherapy with radiotherapy
title_short Current clinical trials testing the combination of immunotherapy with radiotherapy
title_sort current clinical trials testing the combination of immunotherapy with radiotherapy
topic Clinical Trials Monitor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028964/
https://www.ncbi.nlm.nih.gov/pubmed/27660705
http://dx.doi.org/10.1186/s40425-016-0156-7
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