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First case report of infection due to Cupriavidus gilardii in a patient without immunodeficiency: a case report

BACKGROUND: Cupriavidus gilardii is an aerobic, Gram-negative, glucose-nonfermenting rod that was first identified in 1999. Because of the difficulty in accurate species identification of C. gilardii, there are few case reports of infection caused by this organism. In previous reports, C. gilardii h...

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Autores principales: Kobayashi, Takehito, Nakamura, Itaru, Fujita, Hiroaki, Tsukimori, Ayaka, Sato, Akihiro, Fukushima, Shinji, Ohkusu, Kiyofumi, Matsumoto, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029082/
https://www.ncbi.nlm.nih.gov/pubmed/27643790
http://dx.doi.org/10.1186/s12879-016-1838-y
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author Kobayashi, Takehito
Nakamura, Itaru
Fujita, Hiroaki
Tsukimori, Ayaka
Sato, Akihiro
Fukushima, Shinji
Ohkusu, Kiyofumi
Matsumoto, Tetsuya
author_facet Kobayashi, Takehito
Nakamura, Itaru
Fujita, Hiroaki
Tsukimori, Ayaka
Sato, Akihiro
Fukushima, Shinji
Ohkusu, Kiyofumi
Matsumoto, Tetsuya
author_sort Kobayashi, Takehito
collection PubMed
description BACKGROUND: Cupriavidus gilardii is an aerobic, Gram-negative, glucose-nonfermenting rod that was first identified in 1999. Because of the difficulty in accurate species identification of C. gilardii, there are few case reports of infection caused by this organism. In previous reports, C. gilardii has been characterized as an organism with low pathogenicity that causes opportunistic infections. CASE PRESENTATION: We encountered a case of pacemaker-associated bloodstream infection caused by C. gilardii in a 90-year old woman without obvious immunodeficiency. We identified the isolates as C. gilardii by sequencing of the 16S rRNA gene. The patient was treated with removal of the lead and administration of antimicrobial agents. Because of the acquisition of antibiotic resistance during antibiotic treatment, the antimicrobial agent was changed during the course of treatment. CONCLUSIONS: To our knowledge, this is the first report of an infection caused by this organism in a patient without obvious immunodeficiency. Although the true pathogenicity of C. gilardii is unclear, the possibility that it exerts pathogenicity not only in persons with immunodeficiency but also in immunocompetent persons is suggested.
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spelling pubmed-50290822016-09-27 First case report of infection due to Cupriavidus gilardii in a patient without immunodeficiency: a case report Kobayashi, Takehito Nakamura, Itaru Fujita, Hiroaki Tsukimori, Ayaka Sato, Akihiro Fukushima, Shinji Ohkusu, Kiyofumi Matsumoto, Tetsuya BMC Infect Dis Case Report BACKGROUND: Cupriavidus gilardii is an aerobic, Gram-negative, glucose-nonfermenting rod that was first identified in 1999. Because of the difficulty in accurate species identification of C. gilardii, there are few case reports of infection caused by this organism. In previous reports, C. gilardii has been characterized as an organism with low pathogenicity that causes opportunistic infections. CASE PRESENTATION: We encountered a case of pacemaker-associated bloodstream infection caused by C. gilardii in a 90-year old woman without obvious immunodeficiency. We identified the isolates as C. gilardii by sequencing of the 16S rRNA gene. The patient was treated with removal of the lead and administration of antimicrobial agents. Because of the acquisition of antibiotic resistance during antibiotic treatment, the antimicrobial agent was changed during the course of treatment. CONCLUSIONS: To our knowledge, this is the first report of an infection caused by this organism in a patient without obvious immunodeficiency. Although the true pathogenicity of C. gilardii is unclear, the possibility that it exerts pathogenicity not only in persons with immunodeficiency but also in immunocompetent persons is suggested. BioMed Central 2016-09-19 /pmc/articles/PMC5029082/ /pubmed/27643790 http://dx.doi.org/10.1186/s12879-016-1838-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kobayashi, Takehito
Nakamura, Itaru
Fujita, Hiroaki
Tsukimori, Ayaka
Sato, Akihiro
Fukushima, Shinji
Ohkusu, Kiyofumi
Matsumoto, Tetsuya
First case report of infection due to Cupriavidus gilardii in a patient without immunodeficiency: a case report
title First case report of infection due to Cupriavidus gilardii in a patient without immunodeficiency: a case report
title_full First case report of infection due to Cupriavidus gilardii in a patient without immunodeficiency: a case report
title_fullStr First case report of infection due to Cupriavidus gilardii in a patient without immunodeficiency: a case report
title_full_unstemmed First case report of infection due to Cupriavidus gilardii in a patient without immunodeficiency: a case report
title_short First case report of infection due to Cupriavidus gilardii in a patient without immunodeficiency: a case report
title_sort first case report of infection due to cupriavidus gilardii in a patient without immunodeficiency: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029082/
https://www.ncbi.nlm.nih.gov/pubmed/27643790
http://dx.doi.org/10.1186/s12879-016-1838-y
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