The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?

Mesenchymal stem cells (MSCs) are multipotent adult stem cells. MSCs and their potential for use in regenerative medicine have been investigated extensively. Recently, the mechanisms by which MSCs detect mechanical stimuli have been described in detail. As in other cell types, both mechanosensitive...

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Detalles Bibliográficos
Autores principales: Xiao, E., Chen, Chider, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029093/
https://www.ncbi.nlm.nih.gov/pubmed/27651019
http://dx.doi.org/10.1186/s13287-016-0397-x
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author Xiao, E.
Chen, Chider
Zhang, Yi
author_facet Xiao, E.
Chen, Chider
Zhang, Yi
author_sort Xiao, E.
collection PubMed
description Mesenchymal stem cells (MSCs) are multipotent adult stem cells. MSCs and their potential for use in regenerative medicine have been investigated extensively. Recently, the mechanisms by which MSCs detect mechanical stimuli have been described in detail. As in other cell types, both mechanosensitive channels, such as transient receptor potential melastatin 7 (TRPM7), and the cytoskeleton, including actin and actomyosin, have been implicated in mechanosensation in MSCs. This review will focus on discussing the precise role of TRPM7 and the cytoskeleton in mechanosensation in MSCs.
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spelling pubmed-50290932016-09-27 The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton? Xiao, E. Chen, Chider Zhang, Yi Stem Cell Res Ther Viewpoint Mesenchymal stem cells (MSCs) are multipotent adult stem cells. MSCs and their potential for use in regenerative medicine have been investigated extensively. Recently, the mechanisms by which MSCs detect mechanical stimuli have been described in detail. As in other cell types, both mechanosensitive channels, such as transient receptor potential melastatin 7 (TRPM7), and the cytoskeleton, including actin and actomyosin, have been implicated in mechanosensation in MSCs. This review will focus on discussing the precise role of TRPM7 and the cytoskeleton in mechanosensation in MSCs. BioMed Central 2016-09-20 /pmc/articles/PMC5029093/ /pubmed/27651019 http://dx.doi.org/10.1186/s13287-016-0397-x Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Viewpoint
Xiao, E.
Chen, Chider
Zhang, Yi
The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?
title The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?
title_full The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?
title_fullStr The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?
title_full_unstemmed The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?
title_short The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?
title_sort mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029093/
https://www.ncbi.nlm.nih.gov/pubmed/27651019
http://dx.doi.org/10.1186/s13287-016-0397-x
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