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Relapse after Oral Terbinafine Therapy in Dermatophytosis: A Clinical and Mycological Study
BACKGROUND: The incidence of recurrent tinea infections after oral terbinafine therapy is on the rise. AIM: This study aims to identify the appearance of incomplete cure and relapse after 2-week oral terbinafine therapy in tinea corporis and/or tinea cruris. MATERIALS AND METHODS: A total of 100 con...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029239/ https://www.ncbi.nlm.nih.gov/pubmed/27688443 http://dx.doi.org/10.4103/0019-5154.190120 |
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author | Majid, Imran Sheikh, Gousia Kanth, Farhath Hakak, Rubeena |
author_facet | Majid, Imran Sheikh, Gousia Kanth, Farhath Hakak, Rubeena |
author_sort | Majid, Imran |
collection | PubMed |
description | BACKGROUND: The incidence of recurrent tinea infections after oral terbinafine therapy is on the rise. AIM: This study aims to identify the appearance of incomplete cure and relapse after 2-week oral terbinafine therapy in tinea corporis and/or tinea cruris. MATERIALS AND METHODS: A total of 100 consecutive patients clinically and mycologically diagnosed to have tinea corporis and/or tinea cruris were included in the study. The enrolled patients were administered oral terbinafine 250 mg once daily for 2 weeks. All clinically cured patients were then followed up for 12 weeks to look for any relapse/cure. RESULTS: The common dermatophytes grown on culture were Trichophyton rubrum and Trichophyton tonsurans in 55% and 20% patients, respectively. At the end of 2-week oral terbinafine therapy, 30% patients showed a persistent disease on clinical examination while 35% patients showed a persistent positive fungal culture (persisters) at this time. These culture positive patients included all the clinically positive cases. Rest of the patients (65/100) demonstrated both clinical and mycological cure at this time (cured). Over the 12-week follow-up, clinical relapse was seen in 22 more patients (relapse) among those who had shown clinical and mycological cure at the end of terbinafine therapy. Thus, only 43% patients could achieve a long-term clinical and mycological cure after 2 weeks of oral terbinafine treatment. Majority of the relapses (16/22) were seen after 8 weeks of completion of treatment. There was no statistically significant difference in the body surface area involvement or the causative organism involved between the cured, persister, or relapse groups. CONCLUSIONS: Incomplete mycological cure as well as relapse is very common after standard (2-week) terbinafine therapy in our patients of tinea cruris/corporis. |
format | Online Article Text |
id | pubmed-5029239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-50292392016-09-29 Relapse after Oral Terbinafine Therapy in Dermatophytosis: A Clinical and Mycological Study Majid, Imran Sheikh, Gousia Kanth, Farhath Hakak, Rubeena Indian J Dermatol Original Article BACKGROUND: The incidence of recurrent tinea infections after oral terbinafine therapy is on the rise. AIM: This study aims to identify the appearance of incomplete cure and relapse after 2-week oral terbinafine therapy in tinea corporis and/or tinea cruris. MATERIALS AND METHODS: A total of 100 consecutive patients clinically and mycologically diagnosed to have tinea corporis and/or tinea cruris were included in the study. The enrolled patients were administered oral terbinafine 250 mg once daily for 2 weeks. All clinically cured patients were then followed up for 12 weeks to look for any relapse/cure. RESULTS: The common dermatophytes grown on culture were Trichophyton rubrum and Trichophyton tonsurans in 55% and 20% patients, respectively. At the end of 2-week oral terbinafine therapy, 30% patients showed a persistent disease on clinical examination while 35% patients showed a persistent positive fungal culture (persisters) at this time. These culture positive patients included all the clinically positive cases. Rest of the patients (65/100) demonstrated both clinical and mycological cure at this time (cured). Over the 12-week follow-up, clinical relapse was seen in 22 more patients (relapse) among those who had shown clinical and mycological cure at the end of terbinafine therapy. Thus, only 43% patients could achieve a long-term clinical and mycological cure after 2 weeks of oral terbinafine treatment. Majority of the relapses (16/22) were seen after 8 weeks of completion of treatment. There was no statistically significant difference in the body surface area involvement or the causative organism involved between the cured, persister, or relapse groups. CONCLUSIONS: Incomplete mycological cure as well as relapse is very common after standard (2-week) terbinafine therapy in our patients of tinea cruris/corporis. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5029239/ /pubmed/27688443 http://dx.doi.org/10.4103/0019-5154.190120 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Majid, Imran Sheikh, Gousia Kanth, Farhath Hakak, Rubeena Relapse after Oral Terbinafine Therapy in Dermatophytosis: A Clinical and Mycological Study |
title | Relapse after Oral Terbinafine Therapy in Dermatophytosis: A Clinical and Mycological Study |
title_full | Relapse after Oral Terbinafine Therapy in Dermatophytosis: A Clinical and Mycological Study |
title_fullStr | Relapse after Oral Terbinafine Therapy in Dermatophytosis: A Clinical and Mycological Study |
title_full_unstemmed | Relapse after Oral Terbinafine Therapy in Dermatophytosis: A Clinical and Mycological Study |
title_short | Relapse after Oral Terbinafine Therapy in Dermatophytosis: A Clinical and Mycological Study |
title_sort | relapse after oral terbinafine therapy in dermatophytosis: a clinical and mycological study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029239/ https://www.ncbi.nlm.nih.gov/pubmed/27688443 http://dx.doi.org/10.4103/0019-5154.190120 |
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