Granular IgM Deposition at Basement Membrane Zone in an Infant with Diffuse Cutaneous Mastocytosis

Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direc...

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Autores principales: Kumudhini, Subramanian, Rao, Raghavendra, Salgaonkar, Gauri, Shetty, Sricharith, Pai, Sathish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
E-IJD Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029263/
https://www.ncbi.nlm.nih.gov/pubmed/27688466
http://dx.doi.org/10.4103/0019-5154.190134
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author Kumudhini, Subramanian
Rao, Raghavendra
Salgaonkar, Gauri
Shetty, Sricharith
Pai, Sathish
author_facet Kumudhini, Subramanian
Rao, Raghavendra
Salgaonkar, Gauri
Shetty, Sricharith
Pai, Sathish
author_sort Kumudhini, Subramanian
collection PubMed
description Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direct immunofluorescence microscopy of perilesional skin revealed nonspecific deposition of IgM in granular pattern along the dermoepidermal junction.
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spelling pubmed-50292632016-09-29 Granular IgM Deposition at Basement Membrane Zone in an Infant with Diffuse Cutaneous Mastocytosis Kumudhini, Subramanian Rao, Raghavendra Salgaonkar, Gauri Shetty, Sricharith Pai, Sathish Indian J Dermatol E-IJD Case Report Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direct immunofluorescence microscopy of perilesional skin revealed nonspecific deposition of IgM in granular pattern along the dermoepidermal junction. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5029263/ /pubmed/27688466 http://dx.doi.org/10.4103/0019-5154.190134 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle E-IJD Case Report
Kumudhini, Subramanian
Rao, Raghavendra
Salgaonkar, Gauri
Shetty, Sricharith
Pai, Sathish
Granular IgM Deposition at Basement Membrane Zone in an Infant with Diffuse Cutaneous Mastocytosis
title Granular IgM Deposition at Basement Membrane Zone in an Infant with Diffuse Cutaneous Mastocytosis
title_full Granular IgM Deposition at Basement Membrane Zone in an Infant with Diffuse Cutaneous Mastocytosis
title_fullStr Granular IgM Deposition at Basement Membrane Zone in an Infant with Diffuse Cutaneous Mastocytosis
title_full_unstemmed Granular IgM Deposition at Basement Membrane Zone in an Infant with Diffuse Cutaneous Mastocytosis
title_short Granular IgM Deposition at Basement Membrane Zone in an Infant with Diffuse Cutaneous Mastocytosis
title_sort granular igm deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis
topic E-IJD Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029263/
https://www.ncbi.nlm.nih.gov/pubmed/27688466
http://dx.doi.org/10.4103/0019-5154.190134
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