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Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?

As the need for new and more effective antibiotics increases, untapped sources of biodiversity are being explored in an effort to provide lead structures for drug discovery. Endophytic fungi from marine macroalgae have been identified as a potential source of biologically active natural products, al...

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Detalles Bibliográficos
Autores principales: Flewelling, Andrew J., Ellsworth, Katelyn T., Sanford, Joseph, Forward, Erica, Johnson, John A., Gray, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029488/
https://www.ncbi.nlm.nih.gov/pubmed/27694771
http://dx.doi.org/10.3390/microorganisms1010175
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author Flewelling, Andrew J.
Ellsworth, Katelyn T.
Sanford, Joseph
Forward, Erica
Johnson, John A.
Gray, Christopher A.
author_facet Flewelling, Andrew J.
Ellsworth, Katelyn T.
Sanford, Joseph
Forward, Erica
Johnson, John A.
Gray, Christopher A.
author_sort Flewelling, Andrew J.
collection PubMed
description As the need for new and more effective antibiotics increases, untapped sources of biodiversity are being explored in an effort to provide lead structures for drug discovery. Endophytic fungi from marine macroalgae have been identified as a potential source of biologically active natural products, although data to support this is limited. To assess the antibiotic potential of temperate macroalgal endophytes we isolated endophytic fungi from algae collected in the Bay of Fundy, Canada and screened fungal extracts for the presence of antimicrobial compounds. A total of 79 endophytes were isolated from 7 species of red, 4 species of brown, and 3 species of green algae. Twenty of the endophytes were identified to the genus or species level, with the remaining isolates designated codes according to their morphology. Bioactivity screening assays performed on extracts of the fermentation broths and mycelia of the isolates revealed that 43 endophytes exhibited antibacterial activity, with 32 displaying antifungal activity. Endophytic fungi from Bay of Fundy macroalgae therefore represent a significant source of antibiotic natural products and warrant further detailed investigation.
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spelling pubmed-50294882016-09-28 Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products? Flewelling, Andrew J. Ellsworth, Katelyn T. Sanford, Joseph Forward, Erica Johnson, John A. Gray, Christopher A. Microorganisms Article As the need for new and more effective antibiotics increases, untapped sources of biodiversity are being explored in an effort to provide lead structures for drug discovery. Endophytic fungi from marine macroalgae have been identified as a potential source of biologically active natural products, although data to support this is limited. To assess the antibiotic potential of temperate macroalgal endophytes we isolated endophytic fungi from algae collected in the Bay of Fundy, Canada and screened fungal extracts for the presence of antimicrobial compounds. A total of 79 endophytes were isolated from 7 species of red, 4 species of brown, and 3 species of green algae. Twenty of the endophytes were identified to the genus or species level, with the remaining isolates designated codes according to their morphology. Bioactivity screening assays performed on extracts of the fermentation broths and mycelia of the isolates revealed that 43 endophytes exhibited antibacterial activity, with 32 displaying antifungal activity. Endophytic fungi from Bay of Fundy macroalgae therefore represent a significant source of antibiotic natural products and warrant further detailed investigation. MDPI 2013-12-12 /pmc/articles/PMC5029488/ /pubmed/27694771 http://dx.doi.org/10.3390/microorganisms1010175 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Flewelling, Andrew J.
Ellsworth, Katelyn T.
Sanford, Joseph
Forward, Erica
Johnson, John A.
Gray, Christopher A.
Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?
title Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?
title_full Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?
title_fullStr Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?
title_full_unstemmed Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?
title_short Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?
title_sort macroalgal endophytes from the atlantic coast of canada: a potential source of antibiotic natural products?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029488/
https://www.ncbi.nlm.nih.gov/pubmed/27694771
http://dx.doi.org/10.3390/microorganisms1010175
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