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NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K–AKT and JAK–STAT3 pathways

Loss of PTEN, a negative regulator of the phosphoinositide 3-kinase signaling pathway, is a frequent event in T-cell acute lymphoblastic leukemia, suggesting the importance of phosphoinositide 3-kinase activity in this disease. Indeed, hyperactivation of the phosphoinositide 3-kinase pathway is asso...

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Detalles Bibliográficos
Autores principales:	Yuzugullu, Haluk, Von, Thanh, Thorpe, Lauren M, Walker, Sarah R, Roberts, Thomas M, Frank, David A, Zhao, Jean J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029543/ https://www.ncbi.nlm.nih.gov/pubmed/27672444 http://dx.doi.org/10.1038/celldisc.2016.30

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