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Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity
OBJECTIVE: Excessive weight gain frequently occurs in patients with hypothalamic tumors and lesions leading to hypothalamic obesity (HO). METHODS: Digital brain magnetic resonance imaging (MRI) and clinical outcomes were studied retrospectively in a single center, including 45 children with postoper...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029599/ https://www.ncbi.nlm.nih.gov/pubmed/25884561 http://dx.doi.org/10.1002/oby.21067 |
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author | Roth, Christian L. Eslamy, Hedieh Werny, David Elfers, Clinton Shaffer, Michele L. Pihoker, Catherine Ojemann, Jeffrey Dobyns, William B. |
author_facet | Roth, Christian L. Eslamy, Hedieh Werny, David Elfers, Clinton Shaffer, Michele L. Pihoker, Catherine Ojemann, Jeffrey Dobyns, William B. |
author_sort | Roth, Christian L. |
collection | PubMed |
description | OBJECTIVE: Excessive weight gain frequently occurs in patients with hypothalamic tumors and lesions leading to hypothalamic obesity (HO). METHODS: Digital brain magnetic resonance imaging (MRI) and clinical outcomes were studied retrospectively in a single center, including 45 children with postoperative lesions in the sellar region (41 craniopharyngiomas, 4 with Rathke's cleft cysts), ∼5 years post‐surgery, mean age 13.9 years. Four standard sections covering hypothalamic areas critical to energy homeostasis were used to assess lesions and calculate a hypothalamic lesion score (HLS); the association with HO was examined. RESULTS: Compared to subjects who did not develop HO (n = 23), subjects with HO (n = 22) showed more frequently lesions affecting the third ventricular floor, mammillary bodies, and anterior, medial (all P < 0.05), and most importantly posterior hypothalamus (P < 0.01). The HLS correlated significantly with BMI z‐score changes 12 and 30 months post‐surgery, even after adjusting for potential confounders of gender, age at surgery, surgery date, surgery BMI z‐score, hydrocephalus, and residual hypothalamic tumor (r = 0.34, P = 0.03; r = 0.40, P = 0.02, respectively). Diabetes insipidus was found to be an endocrine marker for HO risk. CONCLUSIONS: The extent of damage following surgery in the sellar region can be assessed by MRI using a novel scoring system for early HO risk assessment. |
format | Online Article Text |
id | pubmed-5029599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50295992016-10-03 Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity Roth, Christian L. Eslamy, Hedieh Werny, David Elfers, Clinton Shaffer, Michele L. Pihoker, Catherine Ojemann, Jeffrey Dobyns, William B. Obesity (Silver Spring) Original Articles OBJECTIVE: Excessive weight gain frequently occurs in patients with hypothalamic tumors and lesions leading to hypothalamic obesity (HO). METHODS: Digital brain magnetic resonance imaging (MRI) and clinical outcomes were studied retrospectively in a single center, including 45 children with postoperative lesions in the sellar region (41 craniopharyngiomas, 4 with Rathke's cleft cysts), ∼5 years post‐surgery, mean age 13.9 years. Four standard sections covering hypothalamic areas critical to energy homeostasis were used to assess lesions and calculate a hypothalamic lesion score (HLS); the association with HO was examined. RESULTS: Compared to subjects who did not develop HO (n = 23), subjects with HO (n = 22) showed more frequently lesions affecting the third ventricular floor, mammillary bodies, and anterior, medial (all P < 0.05), and most importantly posterior hypothalamus (P < 0.01). The HLS correlated significantly with BMI z‐score changes 12 and 30 months post‐surgery, even after adjusting for potential confounders of gender, age at surgery, surgery date, surgery BMI z‐score, hydrocephalus, and residual hypothalamic tumor (r = 0.34, P = 0.03; r = 0.40, P = 0.02, respectively). Diabetes insipidus was found to be an endocrine marker for HO risk. CONCLUSIONS: The extent of damage following surgery in the sellar region can be assessed by MRI using a novel scoring system for early HO risk assessment. John Wiley and Sons Inc. 2015-06 2015-04-17 /pmc/articles/PMC5029599/ /pubmed/25884561 http://dx.doi.org/10.1002/oby.21067 Text en © 2015 The Authors. Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Roth, Christian L. Eslamy, Hedieh Werny, David Elfers, Clinton Shaffer, Michele L. Pihoker, Catherine Ojemann, Jeffrey Dobyns, William B. Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity |
title | Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity |
title_full | Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity |
title_fullStr | Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity |
title_full_unstemmed | Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity |
title_short | Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity |
title_sort | semiquantitative analysis of hypothalamic damage on mri predicts risk for hypothalamic obesity |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029599/ https://www.ncbi.nlm.nih.gov/pubmed/25884561 http://dx.doi.org/10.1002/oby.21067 |
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