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Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model
The Runx genes function as dominant oncogenes that collaborate potently with Myc or loss of p53 to induce lymphoma when over-expressed. Here we examined the requirement for basal Runx1 activity for tumor maintenance in the Eμ-Myc model of Burkitt's lymphoma. While normal Runx1(fl/fl) lymphoid c...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029604/ https://www.ncbi.nlm.nih.gov/pubmed/27056890 http://dx.doi.org/10.18632/oncotarget.8554 |