MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

In this work we show a clinically feasible strategy to convert in situ the own tumor into an endogenous vaccine by coating the melanoma cancerous cells with CD28 costimulatory ligands. This therapeutic approach is aimed at targeting T-cell costimulation to chemotherapy-resistant tumors which are ref...

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Detalles Bibliográficos
Autores principales: Soldevilla, Mario Martínez, Villanueva, Helena, Casares, Noelia, Lasarte, Juan Jose, Bendandi, Maurizio, Inoges, Susana, de Cerio, Ascensión López-Díaz, Pastor, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029619/
https://www.ncbi.nlm.nih.gov/pubmed/26992239
http://dx.doi.org/10.18632/oncotarget.8095

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