Cargando…

Depletion of FAP(+) cells reduces immunosuppressive cells and improves metabolism and functions CD8(+)T cells within tumors

The tumor stroma, which is essential to support growth and metastasis of malignant cells, provides targets for active immunotherapy of cancer. Previous studies have shown that depleting fibroblast activation protein (FAP)-expressing stromal cells reduces tumor progression and concomitantly increases...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ying, Ertl, Hildegund C.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029626/ https://www.ncbi.nlm.nih.gov/pubmed/26943036 http://dx.doi.org/10.18632/oncotarget.7818

Ejemplares similares

Aging: T cell metabolism within tumors
por: Zhang, Ying, et al.
Publicado: (2016)

Coaching tumor-infiltrating CD8(+) T cells to eat right
por: Kurupati, Ral, et al.
Publicado: (2018)

Coaching tumor-infiltrating CD8+ T cells to eat right
por: Kurupati, Raj, et al.
Publicado: (2018)

Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor Progression
por: Zhang, Ying, et al.
Publicado: (2016)

Age-related changes in the gene expression profile of antigen-specific mouse CD8+ T cells can be partially reversed by blockade of the BTLA/CD160 pathways during vaccination
por: Dawany, Noor, et al.
Publicado: (2016)

Age-related changes in B cell metabolism
por: Kurupati, Raj K., et al.
Publicado: (2019)

Prognostic Interactions between FAP+ Fibroblasts and CD8a+ T Cells in Colon Cancer
por: Herrera, Mercedes, et al.
Publicado: (2020)

Adenoviral Vector Vaccines Antigen Transgene
por: Ertl, Hildegund C.J.
Publicado: (2016)

Age-related changes in the transcriptome of antibody-secreting cells
por: Kannan, Senthil, et al.
Publicado: (2016)

T Cell-Mediated Immune Responses to AAV and AAV Vectors
por: Ertl, Hildegund C. J.
Publicado: (2021)

Adenoviruses as vaccine vectors
por: Tatsis, Nia, et al.
Publicado: (2004)

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy
por: Das, Shipra, et al.
Publicado: (2023)

Lenalidomide overcomes the immunosuppression of regulatory CD8(+)CD28(−) T-cells
por: Neuber, Brigitte, et al.
Publicado: (2017)

AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes
por: Hui, Daniel J, et al.
Publicado: (2015)

Spheroids of FAP-Positive Cell Lines as a Model for Screening Drugs That Affect FAP Expression
por: Pleshkan, Victor V., et al.
Publicado: (2023)

COVID-19 Vaccines Based on Adenovirus Vectors
por: Hasanpourghadi, Mohadeseh, et al.
Publicado: (2021)

Autophagy variation within a cell population determines cell fate via selective degradation of Fap-1
por: Gump, Jacob M., et al.
Publicado: (2013)

Functional roles of FAP-α in metabolism, migration and invasion of human cancer cells
por: Mori, Noriko, et al.
Publicado: (2023)

HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8(+) T-cell infiltration into tumors
por: Guan, Lei, et al.
Publicado: (2022)

Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma
por: Wang, Zeyu, et al.
Publicado: (2023)

Random migration precedes stable target cell interactions of tumor-infiltrating T cells
por: Mrass, Paulus, et al.
Publicado: (2006)

B cell responses to the 2011/12-influenza vaccine in the aged
por: Kurupati, Raj K., et al.
Publicado: (2013)

Angioimmunoblastic T-cell lymphoma with predominant CD8+ tumor-infiltrating T-cells is a distinct immune pattern with an immunosuppressive microenvironment
por: Chen, Zihang, et al.
Publicado: (2022)

Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells
por: Cross, Eric W., et al.
Publicado: (2019)

Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma
por: Bughda, Reyisa, et al.
Publicado: (2021)

New human rabies vaccines in the pipeline
por: Fooks, Anthony R., et al.
Publicado: (2019)

Depletion of CD4 and CD8 Positive T Cells Impairs Venous Thrombus Resolution in Mice
por: Mukhopadhyay, Subhradip, et al.
Publicado: (2020)

Depletion of polyfunctional CD26(high)CD8(+) T cells repertoire in chronic lymphocytic leukemia
por: Bozorgmehr, Najmeh, et al.
Publicado: (2023)

BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine
por: Kannan, Senthil, et al.
Publicado: (2015)

Permanent CD8(+) T Cell Depletion Prevents Proteinuria in Active Heymann Nephritis
por: Penny, Mark J., et al.
Publicado: (1998)

CD8(+) T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy
por: Sutter, Pearl A., et al.
Publicado: (2023)

Local Induction of Immunosuppressive CD8(+) T Cells in the Gut-Associated Lymphoid Tissues
por: Fleissner, Diana, et al.
Publicado: (2010)

EV PD-L1 Contributes to Immunosuppressive CD8(+) T Cells in Peripheral Blood of Pediatric Wilms Tumor
por: Zhang, Xiaoxue, et al.
Publicado: (2021)

Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models
por: Chi, Yudan, et al.
Publicado: (2014)

Depletion of CD4 and CD8 T Cells Reduces Acute Disease and Is Not Associated with Hearing Loss in ML29-Infected STAT1-/- Mice
por: Reyna, Rachel A., et al.
Publicado: (2022)

Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8(+) T Cells and Efficiently Reduces Chronic Retroviral Loads
por: Dietze, Kirsten K., et al.
Publicado: (2013)

Drug-Tolerant Cancer Cells Show Reduced Tumor-Initiating Capacity: Depletion of CD44(+) Cells and Evidence for Epigenetic Mechanisms
por: Yan, Hong, et al.
Publicado: (2011)

Cell-specific expression of the FAP gene is regulated by enhancer elements
por: Antonova, Dina V., et al.
Publicado: (2023)

Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells
por: Hutnick, Natalie A., et al.
Publicado: (2009)

Regulatory T cells can prevent memory CD8(+) T-cell-mediated rejection following polymorphonuclear cell depletion
por: Jones, Nick D, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_v8omnnmgfio67v4fci58tdudq2