Cargando…

Genomic landscape of DNA repair genes in cancer

DNA repair genes are frequently mutated in cancer, yet limited data exist regarding the overall genomic landscape and functional implications of these alterations in their entirety. We created comprehensive lists of DNA repair genes and indirect caretakers. Mutation, copy number variation (CNV), a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chae, Young Kwang, Anker, Jonathan F., Carneiro, Benedito A., Chandra, Sunandana, Kaplan, Jason, Kalyan, Aparna, Santa-Maria, Cesar A., Platanias, Leonidas C., Giles, Francis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029628/ https://www.ncbi.nlm.nih.gov/pubmed/27004405 http://dx.doi.org/10.18632/oncotarget.8196

Ejemplares similares

Repurposing metformin for cancer treatment: current clinical studies
por: Chae, Young Kwang, et al.
Publicado: (2016)

Concordance between genomic alterations assessed by next-generation sequencing in tumor tissue or circulating cell-free DNA
por: Chae, Young Kwang, et al.
Publicado: (2016)

Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling
por: Chae, Young Kwang, et al.
Publicado: (2015)

The challenge of developmental therapeutics for adrenocortical carcinoma
por: Costa, Ricardo, et al.
Publicado: (2016)

Spotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives
por: Costa, Ricardo, et al.
Publicado: (2016)

Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application
por: Chae, Young Kwang, et al.
Publicado: (2016)

Current landscape and future of dual anti-CTLA4 and PD-1/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC)
por: Chae, Young Kwang, et al.
Publicado: (2018)

FGFR3-TACC3 fusion in solid tumors: mini review
por: Costa, Ricardo, et al.
Publicado: (2016)

Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma
por: Chae, Young Kwang, et al.
Publicado: (2017)

Developmental therapeutics for inflammatory breast cancer: Biology and translational directions
por: Costa, Ricardo, et al.
Publicado: (2016)

A comprehensive review of heregulins, HER3, and HER4 as potential therapeutic targets in cancer
por: Mota, Jose Mauricio, et al.
Publicado: (2017)

Evolving Therapeutic Strategies for the Classic Philadelphia-Negative Myeloproliferative Neoplasms
por: Kaplan, Jason B., et al.
Publicado: (2016)

Mutations in DNA repair genes are associated with increased neoantigen burden and a distinct immunophenotype in lung squamous cell carcinoma
por: Chae, Young Kwang, et al.
Publicado: (2019)

Pseudoprogression in microsatellite instability-high colorectal cancer during treatment with combination T cell mediated immunotherapy: a case report and literature review
por: Chae, Young Kwang, et al.
Publicado: (2017)

Wnt/beta-catenin pathway: modulating anticancer immune response
por: Pai, Sachin Gopalkrishna, et al.
Publicado: (2017)

Clinical features, diagnostic challenges, and management strategies in checkpoint inhibitor-related pneumonitis
por: Chuzi, Sarah, et al.
Publicado: (2017)

Landscape of circulating tumour DNA in metastatic breast cancer
por: Davis, Andrew A., et al.
Publicado: (2020)

Analyses of selected safety endpoints in phase 1 and late-phase clinical trials of anti-PD-1 and PD-L1 inhibitors: prediction of immune-related toxicities
por: Costa, Ricardo, et al.
Publicado: (2017)

Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition
por: Iqbal, Asneha, et al.
Publicado: (2016)

AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications
por: Vakana, Eliza, et al.
Publicado: (2011)

ULK1 in type I interferon response
por: Saleiro, Diana, et al.
Publicado: (2015)

MNK Proteins as Therapeutic Targets in Leukemia
por: Mazewski, Candice, et al.
Publicado: (2023)

A novel approach to overcome drug resistance in acute myeloid leukemia
por: Mazewski, Candice, et al.
Publicado: (2023)

Emerging Role of Glioma Stem Cells in Mechanisms of Therapy Resistance
por: Eckerdt, Frank, et al.
Publicado: (2023)

Pre-clinical evidence of PIM kinase inhibitor activity in BCR-ABL1 unmutated and mutated Philadelphia chromosome-positive (Ph+) leukemias
por: Curi, Dany A., et al.
Publicado: (2015)

Systematic review and meta-analysis of selected toxicities of approved ALK inhibitors in metastatic non-small cell lung cancer
por: Costa, Rubens Barros, et al.
Publicado: (2018)

Posterior reversible encephalopathy syndrome and takotsubo cardiomyopathy associated with lenvatinib therapy for thyroid cancer: a case report and review
por: Chae, Young Kwang, et al.
Publicado: (2018)

Deregulation of Interferon Signaling in Malignant Cells
por: Katsoulidis, Efstratios, et al.
Publicado: (2010)

Innate Immune Mechanisms and Immunotherapy of Myeloid Malignancies
por: Small, Sara, et al.
Publicado: (2021)

Role of Biomarkers in the Management of Acute Myeloid Leukemia
por: Small, Sara, et al.
Publicado: (2022)

The DNA damage repair landscape in Black women with breast cancer
por: Mazumder, Aloran, et al.
Publicado: (2022)

Resistance mechanisms in melanoma to immuneoncologic therapy with checkpoint inhibitors
por: Fenton, Sarah E., et al.
Publicado: (2019)

Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase
por: Colamonici, Marco, et al.
Publicado: (2015)

Targeting mTOR for the treatment of AML. New agents and new directions
por: Altman, Jessica K., et al.
Publicado: (2011)

Type I and II Interferons in the Anti-Tumor Immune Response
por: Fenton, Sarah E., et al.
Publicado: (2021)

Targeting Cytokines and Their Pathways for the Treatment of Cancer
por: Heimberger, Amy B., et al.
Publicado: (2023)

Dynamic DNA Energy Landscapes and Substrate Complexity in Triplet Repeat Expansion and DNA Repair
por: Völker, Jens, et al.
Publicado: (2019)

Overexpression of adhesion molecules and barrier molecules is associated with differential infiltration of immune cells in non-small cell lung cancer
por: Chae, Young Kwang, et al.
Publicado: (2018)

Cytopenias in Transplant Patients
por: Barry, Maura, et al.
Publicado: (2018)

Harnessing Natural Killer Cells in Cancer Immunotherapy: A Review of Mechanisms and Novel Therapies
por: St-Pierre, Frederique, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mhgiivkij0ghqef3o4jqhj2fq0