Virtual screening-driven repositioning of etoposide as CD44 antagonist in breast cancer cells

CD44 is a receptor for hyaluronan (HA) that promotes epithelial-to-mesenchymal transition (EMT), induces cancer stem cell (CSC) expansion, and favors metastasis. Thus, CD44 is a target for the development of antineoplastic agents. In order to repurpose drugs as CD44 antagonists, we performed consens...

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Detalles Bibliográficos
Autores principales: Aguirre-Alvarado, Charmina, Segura-Cabrera, Aldo, Velázquez-Quesada, Inés, Hernández-Esquivel, Miguel A., García-Pérez, Carlos A., Guerrero-Rodríguez, Sandra L., Ruiz, Angel J., Rodríguez-Moreno, Andrea, Pérez-Tapia, Sonia M., Velasco-Velázquez, Marco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029662/
https://www.ncbi.nlm.nih.gov/pubmed/27009862
http://dx.doi.org/10.18632/oncotarget.8180

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