Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts

Cell line-derived xenografts (CDXs) are an integral part of drug efficacy testing during development of new pharmaceuticals against cancer but their accuracy in predicting clinical responses in patients have been debated. Patient-derived xenografts (PDXs) are thought to be more useful for predictive...

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Detalles Bibliográficos
Autores principales: Bhadury, Joydeep, Einarsdottir, Berglind O., Podraza, Agnieszka, Bagge, Roger Olofsson, Stierner, Ulrika, Ny, Lars, López, Marcela Dávila, Nilsson, Jonas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029664/
https://www.ncbi.nlm.nih.gov/pubmed/27009863
http://dx.doi.org/10.18632/oncotarget.8181

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