Cargando…

Genomic profiling of lung adenocarcinoma patients reveals therapeutic targets and confers clinical benefit when standard molecular testing is negative

Background: Identification of clinically relevant oncogenic drivers in advanced cancer is critical in selecting appropriate targeted therapy. Using next-generation sequencing (NGS)-based clinical cancer gene assay, we performed comprehensive genomic profiling (CGP) of advanced cases of lung adenocar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lim, Sun Min, Kim, Eun Young, Kim, Hye Ryun, Ali, Siraj M., Greenbowe, Joel R., Shim, Hyo Sup, Chang, Hyun, Lim, Seungtaek, Paik, Soonmyung, Cho, Byoung Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029692/ https://www.ncbi.nlm.nih.gov/pubmed/26992220 http://dx.doi.org/10.18632/oncotarget.8138

Ejemplares similares

Screening of ROS1 Rearrangements in Lung Adenocarcinoma by Immunohistochemistry and Comparison with ALK Rearrangements
por: Cha, Yoon Jin, et al.
Publicado: (2014)

Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants
por: Cha, Yoon Jin, et al.
Publicado: (2016)

Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus
por: Lim, Sun Min, et al.
Publicado: (2016)

Brief Report: Heterogeneity of Acquired Resistance Mechanisms to Osimertinib and Savolitinib
por: Lim, Sun Min, et al.
Publicado: (2021)

A Case of Gingival Candidiasis with Bone Destruction on Gastric Cancer Patient Receiving Cytotoxic Chemotherapy
por: Lim, Seungtaek, et al.
Publicado: (2014)

Plasminogen Activator Inhibitor Type 1 (PAI-1) A15T Gene Polymorphism Is Associated with Prognosis in Patients with EGFR Mutation Positive Pulmonary Adenocarcinoma
por: Lim, Ju Eun, et al.
Publicado: (2013)

Predicting treatment outcomes using (18)F-FDG PET biomarkers in patients with non-small-cell lung cancer receiving chemoimmunotherapy
por: Kim, Chang Gon, et al.
Publicado: (2022)

Transglutaminase 2 Expression Predicts Progression Free Survival in Non-Small Cell Lung Cancer Patients Treated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
por: Jeong, Jae-Heon, et al.
Publicado: (2013)

Plasma tumor mutation burden is associated with clinical benefit in patients with non-small cell lung cancer treated with anti-programmed death-1 monotherapy
por: Lee, Jii Bum, et al.
Publicado: (2022)

Mouse–human co-clinical trials demonstrate superior anti-tumour effects of buparlisib (BKM120) and cetuximab combination in squamous cell carcinoma of head and neck
por: Kim, Hye Ryun, et al.
Publicado: (2020)

Plant senescence: how plants know when and how to die
por: Woo, Hye Ryun, et al.
Publicado: (2018)

The frequency and clinical impact of HER2 alterations in lung adenocarcinoma
por: Kim, Eun Kyung, et al.
Publicado: (2017)

Comprehensive analysis of the characteristics and treatment outcomes of patients with non-small cell lung cancer treated with anti-PD-1 therapy in real-world practice
por: Ahn, Beung-Chul, et al.
Publicado: (2019)

An Improved, Assay Platform Agnostic, Absolute Single Sample Breast Cancer Subtype Classifier
por: Seo, Mi-kyoung, et al.
Publicado: (2020)

Targeted sequencing identifies genetic alterations that confer primary resistance to EGFR tyrosine kinase inhibitor (Korean Lung Cancer Consortium)
por: Lim, Sun Min, et al.
Publicado: (2016)

Real World Characteristics and Clinical Outcomes of HER2-Mutant Non–Small Cell Lung Cancer Patients Detected by Next-Generation Sequencing
por: Ahn, Beung-Chul, et al.
Publicado: (2023)

Detection of activating and acquired resistant mutation in plasma from EGFR-mutated NSCLC patients by peptide nucleic acid (PNA) clamping-assisted fluorescence melting curve analysis
por: Kim, Chang Gon, et al.
Publicado: (2017)

Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization
por: Kim, Hye Ryun, et al.
Publicado: (2017)

Cancer Cell Line Panels Empower Genomics-Based Discovery of Precision Cancer Medicine
por: Kim, Hyun Seok, et al.
Publicado: (2015)

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers
por: Ahn, Jin Woo, et al.
Publicado: (2014)

A case of extremely early cervical adenocarcinoma diagnosed only by endocervical curettage with macroscopic pelvic lymph node metastases
por: Jung, Jae Hak, et al.
Publicado: (2019)

Analyses of CNS Response to Osimertinib in Patients with T790M-Positive Advanced NSCLC from ASTRIS Korean Subset, Open-Label Real-World Study
por: Ahn, Beung-Chul, et al.
Publicado: (2021)

Gastric type mucinous endocervical adenocarcinoma of the uterine cervix: very rare and interesting case
por: Park, Chul Min, et al.
Publicado: (2018)

Prognosis of resected invasive mucinous adenocarcinoma compared with the IASLC histologic grading system for invasive nonmucinous adenocarcinoma: Surgical database study in the TKIs era in Korea
por: Woo, Wongi, et al.
Publicado: (2022)

Comprehensive analyses of immunodynamics and immunoreactivity in response to treatment in ALK-positive non-small-cell lung cancer
por: Pyo, Kyoung-Ho, et al.
Publicado: (2020)

The Development of AXL Inhibitors in Lung Cancer: Recent Progress and Challenges
por: Sang, Yun Beom, et al.
Publicado: (2022)

Genomic characteristics of invasive mucinous adenocarcinoma of the lung with multiple pulmonary sites of involvement
por: Kim, Moonsik, et al.
Publicado: (2021)

A phase II study of poziotinib in patients with recurrent and/or metastatic head and neck squamous cell carcinoma
por: Lee, Ji Hyun, et al.
Publicado: (2021)

Establishment and characterization of patient-derived xenografts as paraclinical models for head and neck cancer
por: Kang, Han Na, et al.
Publicado: (2020)

Auxin response factor 2 (ARF2) plays a major role in regulating auxin-mediated leaf longevity
por: Lim, Pyung Ok, et al.
Publicado: (2010)

The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma
por: Kim, Hye Ryun, et al.
Publicado: (2013)

The importance of enhancer methylation for epigenetic regulation of tumorigenesis in squamous lung cancer
por: Cho, Jae-Won, et al.
Publicado: (2022)

Rose (Rosa gallica) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway
por: Lim, Won-Chul, et al.
Publicado: (2020)

Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function
por: Kim, Hye Ryun, et al.
Publicado: (2019)

Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma
por: Lee, Jii Bum, et al.
Publicado: (2021)

Publisher Correction: Overexpression of PVR and PD‑L1 and its association with prognosis in surgically resected squamous cell lung carcinoma
por: Lee, Jii Bum, et al.
Publicado: (2021)

Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma
por: Kim, Seok-Young, et al.
Publicado: (2019)

Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing
por: Chun, You Jin, et al.
Publicado: (2019)

Neoadjuvant therapy for thymic neoplasms reduces tumor volume per 3D-reconstructed images but does not improve the complete resection rate
por: Suh, Jee Won, et al.
Publicado: (2019)

Distinct Characteristics and Clinical Outcomes to Predict the Emergence of MET Amplification in Patients with Non-Small Cell Lung Cancer Who Developed Resistance after Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
por: Ahn, Beung-Chul, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_38rb58a8jl98agd91gf0j3sbsc