Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon

T-LAK cell-originated protein kinase (TOPK), a serine/threonine protein kinase, is highly expressed in a variety of tumors and associated with a poor prognosis of human malignancies. However, the activation mechanism of TOPK is still unrevealed. Herein, first we found that Src directly bound with an...

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Detalles Bibliográficos
Autores principales: Xiao, Juanjuan, Duan, Qiuhong, Wang, Zhe, Yan, Wei, Sun, Huimin, Xue, Peipei, Fan, Xiaoming, Zeng, Xiaoyu, Chen, Juan, Shao, Chen, Zhu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029716/
https://www.ncbi.nlm.nih.gov/pubmed/27016416
http://dx.doi.org/10.18632/oncotarget.8231

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