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Acute and subchronic toxicity of 20  kHz and 60  kHz magnetic fields in rats

Despite increasing use of intermediate frequency (IF) magnetic fields (MFs) in occupational and domestic settings, scientific evidence necessary for health risk assessments of IF MF is insufficient. Male and female Crl:CD(SD) rats (12 per sex per group) were exposed to 20 kHz, 0.20 mT(root mean squa...

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Autores principales: Nishimura, Izumi, Oshima, Atsushi, Shibuya, Kazumoto, Mitani, Takashi, Negishi, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029766/
https://www.ncbi.nlm.nih.gov/pubmed/25982482
http://dx.doi.org/10.1002/jat.3161
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author Nishimura, Izumi
Oshima, Atsushi
Shibuya, Kazumoto
Mitani, Takashi
Negishi, Tadashi
author_facet Nishimura, Izumi
Oshima, Atsushi
Shibuya, Kazumoto
Mitani, Takashi
Negishi, Tadashi
author_sort Nishimura, Izumi
collection PubMed
description Despite increasing use of intermediate frequency (IF) magnetic fields (MFs) in occupational and domestic settings, scientific evidence necessary for health risk assessments of IF MF is insufficient. Male and female Crl:CD(SD) rats (12 per sex per group) were exposed to 20 kHz, 0.20 mT(root mean square, rms) or 60 kHz, 0.10 mT(rms) sinusoidal MFs for 22 h day(−1) for 14 days (acute) or 13 weeks (subchronic). Experiments were duplicated for each frequency to ensure outcome reproducibility, and examinations were blinded for quality assurance. All rats survived without significant clinical signs until the end of experiments. Some changes in body weight between the MF‐exposed and control groups were observed over the course of exposure, although the directions of the changes were inconsistent and not statistically significant after subchronic exposure. There were significant differences between MF‐exposed and control groups in some organ weights and parameters in hematology and clinical chemistry, but these were minor in magnitude and not repeated in duplicate experiments. Histopathological findings reflecting toxicity were sporadic. Frequencies of other findings were similar to historic data in this rat strain, and findings had no specific relationship to changes in organ weight or parameters of hematology and clinical chemistry in each animal. The changes observed throughout this study were considered biologically isolated and were attributable to chance associations rather than to MF exposure. The results, in particular the histopathological evidence, indicate an absence of toxicity in IF MF‐exposed rats and do not support the hypothesis that IF MF exposure produces significant toxicity. Copyright © 2015. The Authors. Journal of Applied Toxicology Published by John Wiley & Sons Ltd.
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spelling pubmed-50297662016-10-03 Acute and subchronic toxicity of 20  kHz and 60  kHz magnetic fields in rats Nishimura, Izumi Oshima, Atsushi Shibuya, Kazumoto Mitani, Takashi Negishi, Tadashi J Appl Toxicol Research Articles Despite increasing use of intermediate frequency (IF) magnetic fields (MFs) in occupational and domestic settings, scientific evidence necessary for health risk assessments of IF MF is insufficient. Male and female Crl:CD(SD) rats (12 per sex per group) were exposed to 20 kHz, 0.20 mT(root mean square, rms) or 60 kHz, 0.10 mT(rms) sinusoidal MFs for 22 h day(−1) for 14 days (acute) or 13 weeks (subchronic). Experiments were duplicated for each frequency to ensure outcome reproducibility, and examinations were blinded for quality assurance. All rats survived without significant clinical signs until the end of experiments. Some changes in body weight between the MF‐exposed and control groups were observed over the course of exposure, although the directions of the changes were inconsistent and not statistically significant after subchronic exposure. There were significant differences between MF‐exposed and control groups in some organ weights and parameters in hematology and clinical chemistry, but these were minor in magnitude and not repeated in duplicate experiments. Histopathological findings reflecting toxicity were sporadic. Frequencies of other findings were similar to historic data in this rat strain, and findings had no specific relationship to changes in organ weight or parameters of hematology and clinical chemistry in each animal. The changes observed throughout this study were considered biologically isolated and were attributable to chance associations rather than to MF exposure. The results, in particular the histopathological evidence, indicate an absence of toxicity in IF MF‐exposed rats and do not support the hypothesis that IF MF exposure produces significant toxicity. Copyright © 2015. The Authors. Journal of Applied Toxicology Published by John Wiley & Sons Ltd. John Wiley and Sons Inc. 2015-05-17 2016-02 /pmc/articles/PMC5029766/ /pubmed/25982482 http://dx.doi.org/10.1002/jat.3161 Text en Copyright © 2015. The Authors. Journal of Applied Toxicology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Nishimura, Izumi
Oshima, Atsushi
Shibuya, Kazumoto
Mitani, Takashi
Negishi, Tadashi
Acute and subchronic toxicity of 20  kHz and 60  kHz magnetic fields in rats
title Acute and subchronic toxicity of 20  kHz and 60  kHz magnetic fields in rats
title_full Acute and subchronic toxicity of 20  kHz and 60  kHz magnetic fields in rats
title_fullStr Acute and subchronic toxicity of 20  kHz and 60  kHz magnetic fields in rats
title_full_unstemmed Acute and subchronic toxicity of 20  kHz and 60  kHz magnetic fields in rats
title_short Acute and subchronic toxicity of 20  kHz and 60  kHz magnetic fields in rats
title_sort acute and subchronic toxicity of 20  khz and 60  khz magnetic fields in rats
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029766/
https://www.ncbi.nlm.nih.gov/pubmed/25982482
http://dx.doi.org/10.1002/jat.3161
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