Lamivudine/Adefovir Treatment Increases the Rate of Spontaneous Mutation of Hepatitis B Virus in Patients

The high levels of genetic diversity shown by hepatitis B virus (HBV) are commonly attributed to the low fidelity of its polymerase. However, the rate of spontaneous mutation of human HBV in vivo is currently unknown. Here, based on the evolutionary principle that the population frequency of lethal...

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Detalles Bibliográficos
Autores principales: Pereira-Gómez, Marianoel, Bou, Juan-Vicente, Andreu, Iván, Sanjuán, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029863/
https://www.ncbi.nlm.nih.gov/pubmed/27649318
http://dx.doi.org/10.1371/journal.pone.0163363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029863/
https://www.ncbi.nlm.nih.gov/pubmed/27649318
http://dx.doi.org/10.1371/journal.pone.0163363

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