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Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKL

Cytokines play a key role in the bone destruction of rheumatoid arthritis (RA). Interleukin-21 (IL-21) promotes osteoclastogenesis in RA in a receptor activator of nuclear factor-κB ligand (RANKL)-dependent way. Whether IL-21 is capable of promoting osteoclastogenesis directly in the absence of RANK...

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Detalles Bibliográficos
Autores principales:	Xing, Rui, Zhang, Yingjian, Li, Changhong, Sun, Lin, Yang, Lin, Zhao, Jinxia, Liu, Xiangyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029957/ https://www.ncbi.nlm.nih.gov/pubmed/27599586 http://dx.doi.org/10.3892/ijmm.2016.2722

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