The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review)

Corneal alkali burns (CAB) are characterized by injury-induced inflammation, fibrosis and neovascularization (NV), and may lead to blindness. This review evaluates the current knowledge of the molecular mechanisms responsible for CAB. The processes of cytokine production, chemotaxis, inflammatory re...

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Autores principales: Zhou, Hongyan, Zhang, Wensong, Bi, Miaomiao, Wu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029963/
https://www.ncbi.nlm.nih.gov/pubmed/27499172
http://dx.doi.org/10.3892/ijmm.2016.2699
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author Zhou, Hongyan
Zhang, Wensong
Bi, Miaomiao
Wu, Jie
author_facet Zhou, Hongyan
Zhang, Wensong
Bi, Miaomiao
Wu, Jie
author_sort Zhou, Hongyan
collection PubMed
description Corneal alkali burns (CAB) are characterized by injury-induced inflammation, fibrosis and neovascularization (NV), and may lead to blindness. This review evaluates the current knowledge of the molecular mechanisms responsible for CAB. The processes of cytokine production, chemotaxis, inflammatory responses, immune response, cell signal transduction, matrix metalloproteinase production and vascular factors in CAB are discussed. Previous evidence indicates that peroxisome proliferator-activated receptor γ (PPAR-γ) agonists suppress immune responses, inflammation, corneal fibrosis and NV. This review also discusses the role of PPAR-γ as an anti-inflammatory, anti-fibrotic and anti-angiogenic agent in the treatment of CAB, as well as the potential role of PPAR-γ in the pathological process of CAB. There have been numerous studies evaluating the clinical profiles of CAB, and the aim of this systematic review was to summarize the evidence regarding the treatment of CAB with PPAR-γ agonists.
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spelling pubmed-50299632016-09-22 The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review) Zhou, Hongyan Zhang, Wensong Bi, Miaomiao Wu, Jie Int J Mol Med Articles Corneal alkali burns (CAB) are characterized by injury-induced inflammation, fibrosis and neovascularization (NV), and may lead to blindness. This review evaluates the current knowledge of the molecular mechanisms responsible for CAB. The processes of cytokine production, chemotaxis, inflammatory responses, immune response, cell signal transduction, matrix metalloproteinase production and vascular factors in CAB are discussed. Previous evidence indicates that peroxisome proliferator-activated receptor γ (PPAR-γ) agonists suppress immune responses, inflammation, corneal fibrosis and NV. This review also discusses the role of PPAR-γ as an anti-inflammatory, anti-fibrotic and anti-angiogenic agent in the treatment of CAB, as well as the potential role of PPAR-γ in the pathological process of CAB. There have been numerous studies evaluating the clinical profiles of CAB, and the aim of this systematic review was to summarize the evidence regarding the treatment of CAB with PPAR-γ agonists. D.A. Spandidos 2016-10 2016-08-04 /pmc/articles/PMC5029963/ /pubmed/27499172 http://dx.doi.org/10.3892/ijmm.2016.2699 Text en Copyright: © Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhou, Hongyan
Zhang, Wensong
Bi, Miaomiao
Wu, Jie
The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review)
title The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review)
title_full The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review)
title_fullStr The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review)
title_full_unstemmed The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review)
title_short The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review)
title_sort molecular mechanisms of action of ppar-γ agonists in the treatment of corneal alkali burns (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029963/
https://www.ncbi.nlm.nih.gov/pubmed/27499172
http://dx.doi.org/10.3892/ijmm.2016.2699
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