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A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading
Histone lysine-to-methionine (K-to-M) mutations are associated with multiple cancers, and they function in a dominant fashion to block the methylation of corresponding lysines on wild type histones. However, their mechanisms of function are controversial. Here we show that in fission yeast, introduc...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030085/ https://www.ncbi.nlm.nih.gov/pubmed/27648579 http://dx.doi.org/10.7554/eLife.17903 |