Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer. Here, we show that E2 stimulation causes a rapid, global increase in the...

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Detalles Bibliográficos
Autores principales: Stork, Caroline Townsend, Bocek, Michael, Crossley, Madzia P, Sollier, Julie, Sanz, Lionel A, Chédin, Frédéric, Swigut, Tomek, Cimprich, Karlene A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030092/
https://www.ncbi.nlm.nih.gov/pubmed/27552054
http://dx.doi.org/10.7554/eLife.17548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030092/
https://www.ncbi.nlm.nih.gov/pubmed/27552054
http://dx.doi.org/10.7554/eLife.17548

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