Cargando…

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer. Here, we show that E2 stimulation causes a rapid, global increase in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stork, Caroline Townsend, Bocek, Michael, Crossley, Madzia P, Sollier, Julie, Sanz, Lionel A, Chédin, Frédéric, Swigut, Tomek, Cimprich, Karlene A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Genes and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030092/ https://www.ncbi.nlm.nih.gov/pubmed/27552054 http://dx.doi.org/10.7554/eLife.17548

Ejemplares similares

qDRIP: a method to quantitatively assess RNA–DNA hybrid formation genome-wide
por: Crossley, Magdalena P, et al.
Publicado: (2020)

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome
por: Lim, Yoong Wearn, et al.
Publicado: (2015)

Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation
por: Fuentes, Daniel R, et al.
Publicado: (2018)

Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length
por: Shah, Shanaya Shital, et al.
Publicado: (2020)

Bisulfite treatment and single-molecule real-time sequencing reveal D-loop length, position, and distribution
por: Shah, Shanaya Shital, et al.
Publicado: (2020)

RNase H enables efficient repair of R-loop induced DNA damage
por: Amon, Jeremy D, et al.
Publicado: (2016)

Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination
por: Zhao, Hongchang, et al.
Publicado: (2022)

The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells
por: Georges, Adrien, et al.
Publicado: (2014)

Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq
por: Dumelie, Jason G, et al.
Publicado: (2017)

Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells
por: Descostes, Nicolas, et al.
Publicado: (2014)

Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages
por: Eichenfield, Dawn Z, et al.
Publicado: (2016)

Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus
por: Materne, Philippe, et al.
Publicado: (2016)

Promoter nucleosome dynamics regulated by signalling through the CTD code
por: Materne, Philippe, et al.
Publicado: (2015)

Genome-wide Estrogen Receptor-α activation is sustained, not cyclical
por: Holding, Andrew N, et al.
Publicado: (2018)

The interplay between asymmetric and symmetric DNA loop extrusion
por: Banigan, Edward J, et al.
Publicado: (2020)

Non-canonical TAF complexes regulate active promoters in human embryonic stem cells
por: Maston, Glenn A, et al.
Publicado: (2012)

Chromosome organization by one-sided and two-sided loop extrusion
por: Banigan, Edward J, et al.
Publicado: (2020)

Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction
por: Katzenberger, Rebeccah J, et al.
Publicado: (2015)

A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress
por: McMurchy, Alicia N, et al.
Publicado: (2017)

A Brownian ratchet model for DNA loop extrusion by the cohesin complex
por: Higashi, Torahiko L, et al.
Publicado: (2021)

Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops
por: Sabino, João C, et al.
Publicado: (2022)

Cohesin-dependence of neuronal gene expression relates to chromatin loop length
por: Calderon, Lesly, et al.
Publicado: (2022)

Sae2/CtIP prevents R-loop accumulation in eukaryotic cells
por: Makharashvili, Nodar, et al.
Publicado: (2018)

Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells
por: Swygert, Sarah G, et al.
Publicado: (2021)

The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status
por: Li, Dongming, et al.
Publicado: (2017)

A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide
por: Wulfridge, Phillip, et al.
Publicado: (2021)

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding
por: Bao, Chen, et al.
Publicado: (2020)

Condensin DC loads and spreads from recruitment sites to create loop-anchored TADs in C. elegans
por: Kim, Jun, et al.
Publicado: (2022)

Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver
por: Matthews, Bryan J, et al.
Publicado: (2018)

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
por: Zhang, Yuan, et al.
Publicado: (2012)

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis
por: Taylor, Benjamin JM, et al.
Publicado: (2013)

Bidding the CpG island goodbye
por: Greally, John M
Publicado: (2013)

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates
por: Long, Hannah K, et al.
Publicado: (2013)

Plants regenerated from tissue culture contain stable epigenome changes in rice
por: Stroud, Hume, et al.
Publicado: (2013)

A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis
por: Olive, Virginie, et al.
Publicado: (2013)

When 19 is greater than 92
por: Zeitels, Lauren R, et al.
Publicado: (2013)

The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1
por: Skene, Peter J, et al.
Publicado: (2014)

The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo
por: Henikoff, Steven, et al.
Publicado: (2014)

Natural antisense transcripts regulate the neuronal stress response and excitability
por: Zheng, Xingguo, et al.
Publicado: (2014)

Is DNA methylation of tumour suppressor genes epigenetic?
por: Struhl, Kevin
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_tbfgf7mfi6ltd3ejpskm0v2j94