Smac mimetics and innate immune stimuli synergize to promote tumor death

Smac mimetic compounds (SMC), a class of drugs that sensitize cells to apoptosis by counteracting the activity of inhibitor of apoptosis (IAP) proteins, have proven safe in Phase I clinical trials in cancer patients. However, because SMCs act by enabling transduction of pro-apoptotic signals, SMC mo...

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Detalles Bibliográficos
Autores principales: Beug, Shawn T., Tang, Vera A., LaCasse, Eric C., Cheung, Herman H., Beauregard, Caroline E., Brun, Jan, Nuyens, Jeffrey P., Earl, Nathalie, St-Jean, Martine, Holbrook, Janelle, Dastidar, Himika, Mahoney, Douglas J., Ilkow, Carolina, Le Boeuf, Fabrice, Bell, John C., Korneluk, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030098/
https://www.ncbi.nlm.nih.gov/pubmed/24463573
http://dx.doi.org/10.1038/nbt.2806

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