FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions

Guanine-nucleotide dissociation inhibitors (GDI) are negative regulators of Rho family GTPases that sequester the GTPases away from the membrane. Here we ask how GDI-Cdc42 interaction regulates localized Cdc42 activation for cell motility. The sensitivity of cells to overexpression of Rho family pat...

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Detalles Bibliográficos
Autores principales: Hodgson, Louis, Spiering, Désirée, Sabouri-Ghomi, Mohsen, Dagliyan, Onur, DerMardirossian, Céline, Danuser, Gaudenz, Hahn, Klaus M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030135/
https://www.ncbi.nlm.nih.gov/pubmed/27501396
http://dx.doi.org/10.1038/nchembio.2145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030135/
https://www.ncbi.nlm.nih.gov/pubmed/27501396
http://dx.doi.org/10.1038/nchembio.2145

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