A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival

Polyketides and nonribosomal peptides are two important classes of natural products that are produced by many species of bacteria and fungi, but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produce...

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Detalles Bibliográficos
Autores principales: Shou, Qingyao, Feng, Likui, Long, Yaoling, Han, Jungsoo, Nunnery, Joshawna K., Powell, David H., Butcher, Rebecca A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030153/
https://www.ncbi.nlm.nih.gov/pubmed/27501395
http://dx.doi.org/10.1038/nchembio.2144
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author Shou, Qingyao
Feng, Likui
Long, Yaoling
Han, Jungsoo
Nunnery, Joshawna K.
Powell, David H.
Butcher, Rebecca A.
author_facet Shou, Qingyao
Feng, Likui
Long, Yaoling
Han, Jungsoo
Nunnery, Joshawna K.
Powell, David H.
Butcher, Rebecca A.
author_sort Shou, Qingyao
collection PubMed
description Polyketides and nonribosomal peptides are two important classes of natural products that are produced by many species of bacteria and fungi, but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produced in the CAN neurons and promotes survival during starvation-induced larval arrest. Our results uncover a novel mechanism by which animals respond to nutrient fluctuations to extend survival.
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spelling pubmed-50301532017-02-08 A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival Shou, Qingyao Feng, Likui Long, Yaoling Han, Jungsoo Nunnery, Joshawna K. Powell, David H. Butcher, Rebecca A. Nat Chem Biol Article Polyketides and nonribosomal peptides are two important classes of natural products that are produced by many species of bacteria and fungi, but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produced in the CAN neurons and promotes survival during starvation-induced larval arrest. Our results uncover a novel mechanism by which animals respond to nutrient fluctuations to extend survival. 2016-08-08 2016-10 /pmc/articles/PMC5030153/ /pubmed/27501395 http://dx.doi.org/10.1038/nchembio.2144 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Shou, Qingyao
Feng, Likui
Long, Yaoling
Han, Jungsoo
Nunnery, Joshawna K.
Powell, David H.
Butcher, Rebecca A.
A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival
title A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival
title_full A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival
title_fullStr A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival
title_full_unstemmed A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival
title_short A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival
title_sort hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030153/
https://www.ncbi.nlm.nih.gov/pubmed/27501395
http://dx.doi.org/10.1038/nchembio.2144
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