Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer

Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF, and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimat...

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Autores principales: Burke, Lorraine, Butler, Clare T., Murphy, Adrian, Moran, Bruce, Gallagher, William M., O'Sullivan, Jacintha, Kennedy, Breandán N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030284/
https://www.ncbi.nlm.nih.gov/pubmed/27709113
http://dx.doi.org/10.3389/fcell.2016.00103
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author Burke, Lorraine
Butler, Clare T.
Murphy, Adrian
Moran, Bruce
Gallagher, William M.
O'Sullivan, Jacintha
Kennedy, Breandán N.
author_facet Burke, Lorraine
Butler, Clare T.
Murphy, Adrian
Moran, Bruce
Gallagher, William M.
O'Sullivan, Jacintha
Kennedy, Breandán N.
author_sort Burke, Lorraine
collection PubMed
description Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF, and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimately resistance. Cysteinyl leukotriene (CysLT) signaling regulates intestinal homeostasis with mounting evidence suggesting that CysLT signaling also plays a role in the pathogenesis of colorectal cancer. Therefore, CysLT signaling represents a novel target for this malignancy. This review evaluates reported links between CysLT signaling and established hallmarks of cancer in addition to its pharmacological potential as a new therapeutic target.
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spelling pubmed-50302842016-10-05 Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer Burke, Lorraine Butler, Clare T. Murphy, Adrian Moran, Bruce Gallagher, William M. O'Sullivan, Jacintha Kennedy, Breandán N. Front Cell Dev Biol Cell and Developmental Biology Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF, and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimately resistance. Cysteinyl leukotriene (CysLT) signaling regulates intestinal homeostasis with mounting evidence suggesting that CysLT signaling also plays a role in the pathogenesis of colorectal cancer. Therefore, CysLT signaling represents a novel target for this malignancy. This review evaluates reported links between CysLT signaling and established hallmarks of cancer in addition to its pharmacological potential as a new therapeutic target. Frontiers Media S.A. 2016-09-21 /pmc/articles/PMC5030284/ /pubmed/27709113 http://dx.doi.org/10.3389/fcell.2016.00103 Text en Copyright © 2016 Burke, Butler, Murphy, Moran, Gallagher, O'Sullivan and Kennedy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Burke, Lorraine
Butler, Clare T.
Murphy, Adrian
Moran, Bruce
Gallagher, William M.
O'Sullivan, Jacintha
Kennedy, Breandán N.
Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
title Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
title_full Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
title_fullStr Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
title_full_unstemmed Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
title_short Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
title_sort evaluation of cysteinyl leukotriene signaling as a therapeutic target for colorectal cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030284/
https://www.ncbi.nlm.nih.gov/pubmed/27709113
http://dx.doi.org/10.3389/fcell.2016.00103
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