Fibrils of Truncated Pyroglutamyl-Modified Aβ Peptide Exhibit a Similar Structure as Wildtype Mature Aβ Fibrils

Fibrillation of differently modified amyloid β peptides and deposition as senile plaques are hallmarks of Alzheimer’s disease. N-terminally truncated variants, where the glutamate residue 3 is converted into cyclic pyroglutamate (pGlu), form particularly toxic aggregates. We compare the molecular st...

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Detalles Bibliográficos
Autores principales: Scheidt, Holger A., Adler, Juliane, Krueger, Martin, Huster, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030707/
https://www.ncbi.nlm.nih.gov/pubmed/27650059
http://dx.doi.org/10.1038/srep33531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030707/
https://www.ncbi.nlm.nih.gov/pubmed/27650059
http://dx.doi.org/10.1038/srep33531

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