Development of a 3D Tissue Culture–Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases

3D tissue cultures provide a more physiologically relevant context for the screening of compounds, compared with 2D cell cultures. Cells cultured in 3D hydrogels also show complex phenotypes, increasing the scope for phenotypic profiling. Here we describe a high-content screening platform that uses...

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Detalles Bibliográficos
Autores principales: Booij, Tijmen H., Klop, Maarten J. D., Yan, Kuan, Szántai-Kis, Csaba, Szokol, Balint, Orfi, Laszlo, van de Water, Bob, Keri, Gyorgy, Price, Leo S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Special Collection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030728/
https://www.ncbi.nlm.nih.gov/pubmed/27412535
http://dx.doi.org/10.1177/1087057116657269

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