Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression

HIV-1 adapts to a new host through mutations that facilitate immune escape. Here, we evaluate the impact on viral control and disease progression of transmitted polymorphisms that were either preadapted to or nonassociated with the new host’s HLA. In a cohort of 169 Zambian heterosexual transmission...

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Detalles Bibliográficos
Autores principales: Mónaco, Daniela C., Dilernia, Dario A., Fiore-Gartland, Andrew, Yu, Tianwei, Prince, Jessica L., Dennis, Kristine K., Qin, Kai, Schaefer, Malinda, Claiborne, Daniel T., Kilembe, William, Tang, Jianming, Price, Matt A., Farmer, Paul, Gilmour, Jill, Bansal, Anju, Allen, Susan, Goepfert, Paul, Hunter, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030801/
https://www.ncbi.nlm.nih.gov/pubmed/27551154
http://dx.doi.org/10.1084/jem.20151984

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