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Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice

Liposarcomas (LPSs) are the most common soft-tissue cancer. Because of the lack of animal models, the cellular origin and molecular regulation of LPS remain unclear. Here, we report that mice with adipocyte-specific activation of Notch signaling (Ad/N1ICD) develop LPS with complete penetrance. Linea...

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Detalles Bibliográficos
Autores principales:	Bi, Pengpeng, Yue, Feng, Karki, Anju, Castro, Beatriz, Wirbisky, Sara E., Wang, Chao, Durkes, Abigail, Elzey, Bennett D., Andrisani, Ourania M., Bidwell, Christopher A., Freeman, Jennifer L., Konieczny, Stephen F., Kuang, Shihuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030803/ https://www.ncbi.nlm.nih.gov/pubmed/27573812 http://dx.doi.org/10.1084/jem.20160157

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