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Epidemiology, virulence factors and management of the pneumococcus

Pneumococcal infections continue to cause significant morbidity and mortality in patients throughout the world. This microorganism remains the most common bacterial cause of community-acquired pneumonia and is associated with a considerable burden of disease and health-care costs in both developed a...

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Autores principales: Feldman, Charles, Anderson, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031122/
https://www.ncbi.nlm.nih.gov/pubmed/27703671
http://dx.doi.org/10.12688/f1000research.9283.1
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author Feldman, Charles
Anderson, Ronald
author_facet Feldman, Charles
Anderson, Ronald
author_sort Feldman, Charles
collection PubMed
description Pneumococcal infections continue to cause significant morbidity and mortality in patients throughout the world. This microorganism remains the most common bacterial cause of community-acquired pneumonia and is associated with a considerable burden of disease and health-care costs in both developed and developing countries. Emerging antibiotic resistance has been a concern because of its potential negative impact on the outcome of patients who receive standard antibiotic therapy. However, there have been substantial changes in the epidemiology of this pathogen in recent years, not least of which has been due to the use of pneumococcal conjugate vaccines in children, with subsequent herd protection in unvaccinated adults and children. Furthermore, much recent research has led to a better understanding of the virulence factors of this pathogen and their role in the pathogenesis of severe pneumococcal disease, including the cardiac complications, as well as the potential role of adjunctive therapy in the management of severely ill cases. This review will describe recent advances in our understanding of the epidemiology, virulence factors, and management of pneumococcal community-acquired pneumonia.
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spelling pubmed-50311222016-10-03 Epidemiology, virulence factors and management of the pneumococcus Feldman, Charles Anderson, Ronald F1000Res Review Pneumococcal infections continue to cause significant morbidity and mortality in patients throughout the world. This microorganism remains the most common bacterial cause of community-acquired pneumonia and is associated with a considerable burden of disease and health-care costs in both developed and developing countries. Emerging antibiotic resistance has been a concern because of its potential negative impact on the outcome of patients who receive standard antibiotic therapy. However, there have been substantial changes in the epidemiology of this pathogen in recent years, not least of which has been due to the use of pneumococcal conjugate vaccines in children, with subsequent herd protection in unvaccinated adults and children. Furthermore, much recent research has led to a better understanding of the virulence factors of this pathogen and their role in the pathogenesis of severe pneumococcal disease, including the cardiac complications, as well as the potential role of adjunctive therapy in the management of severely ill cases. This review will describe recent advances in our understanding of the epidemiology, virulence factors, and management of pneumococcal community-acquired pneumonia. F1000Research 2016-09-14 /pmc/articles/PMC5031122/ /pubmed/27703671 http://dx.doi.org/10.12688/f1000research.9283.1 Text en Copyright: © 2016 Feldman C and Anderson R http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Feldman, Charles
Anderson, Ronald
Epidemiology, virulence factors and management of the pneumococcus
title Epidemiology, virulence factors and management of the pneumococcus
title_full Epidemiology, virulence factors and management of the pneumococcus
title_fullStr Epidemiology, virulence factors and management of the pneumococcus
title_full_unstemmed Epidemiology, virulence factors and management of the pneumococcus
title_short Epidemiology, virulence factors and management of the pneumococcus
title_sort epidemiology, virulence factors and management of the pneumococcus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031122/
https://www.ncbi.nlm.nih.gov/pubmed/27703671
http://dx.doi.org/10.12688/f1000research.9283.1
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