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Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance

Leishmania has a plastic genome, and drug pressure can select for gene copy number variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to specific genomic regions. For the latter, the amplification of chromosomal regions occurs at the level of homologous direct or...

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Detalles Bibliográficos
Autores principales:	Laffitte, Marie-Claude N., Leprohon, Philippe, Papadopoulou, Barbara, Ouellette, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000Research 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031125/ https://www.ncbi.nlm.nih.gov/pubmed/27703673 http://dx.doi.org/10.12688/f1000research.9218.1

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