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Exaptive origins of regulated mRNA decay in eukaryotes

Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense‐mediated decay (NMD) and motif‐specific transcript de...

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Detalles Bibliográficos
Autores principales: Hamid, Fursham M., Makeyev, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031192/
https://www.ncbi.nlm.nih.gov/pubmed/27438915
http://dx.doi.org/10.1002/bies.201600100
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author Hamid, Fursham M.
Makeyev, Eugene V.
author_facet Hamid, Fursham M.
Makeyev, Eugene V.
author_sort Hamid, Fursham M.
collection PubMed
description Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense‐mediated decay (NMD) and motif‐specific transcript destabilization by CCCH‐type zinc finger RNA‐binding proteins, originated as a part of cellular defense against RNA pathogens. These branches of the mRNA turnover pathway might have been used by primeval eukaryotes alongside RNA interference to distinguish their own messages from those of RNA viruses and retrotransposable elements. We further hypothesize that the subsequent advent of “professional” innate and adaptive immunity systems allowed NMD and the motif‐triggered mechanisms to be efficiently repurposed for regulation of endogenous cellular transcripts. This scenario explains the rapid emergence of archetypical mRNA destabilization pathways in eukaryotes and argues that other aspects of post‐transcriptional gene regulation in this lineage might have been derived through a similar exaptation route.
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spelling pubmed-50311922016-10-03 Exaptive origins of regulated mRNA decay in eukaryotes Hamid, Fursham M. Makeyev, Eugene V. Bioessays Insights & Perspectives Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense‐mediated decay (NMD) and motif‐specific transcript destabilization by CCCH‐type zinc finger RNA‐binding proteins, originated as a part of cellular defense against RNA pathogens. These branches of the mRNA turnover pathway might have been used by primeval eukaryotes alongside RNA interference to distinguish their own messages from those of RNA viruses and retrotransposable elements. We further hypothesize that the subsequent advent of “professional” innate and adaptive immunity systems allowed NMD and the motif‐triggered mechanisms to be efficiently repurposed for regulation of endogenous cellular transcripts. This scenario explains the rapid emergence of archetypical mRNA destabilization pathways in eukaryotes and argues that other aspects of post‐transcriptional gene regulation in this lineage might have been derived through a similar exaptation route. John Wiley and Sons Inc. 2016-07-20 2016-09 /pmc/articles/PMC5031192/ /pubmed/27438915 http://dx.doi.org/10.1002/bies.201600100 Text en © 2016 The Authors BioEssays Published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Insights & Perspectives
Hamid, Fursham M.
Makeyev, Eugene V.
Exaptive origins of regulated mRNA decay in eukaryotes
title Exaptive origins of regulated mRNA decay in eukaryotes
title_full Exaptive origins of regulated mRNA decay in eukaryotes
title_fullStr Exaptive origins of regulated mRNA decay in eukaryotes
title_full_unstemmed Exaptive origins of regulated mRNA decay in eukaryotes
title_short Exaptive origins of regulated mRNA decay in eukaryotes
title_sort exaptive origins of regulated mrna decay in eukaryotes
topic Insights & Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031192/
https://www.ncbi.nlm.nih.gov/pubmed/27438915
http://dx.doi.org/10.1002/bies.201600100
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