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P53 and the defenses against genome instability caused by transposons and repetitive elements

The recent publication by Wylie et al. is reviewed, demonstrating that the p53 protein regulates the movement of transposons. While this work presents genetic evidence for a piRNA‐mediated p53 interaction with transposons in Drosophila and zebrafish, it is herein placed in the context of a decade or...

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Detalles Bibliográficos
Autores principales: Levine, Arnold J., Ting, David T., Greenbaum, Benjamin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031199/
https://www.ncbi.nlm.nih.gov/pubmed/27172878
http://dx.doi.org/10.1002/bies.201600031
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author Levine, Arnold J.
Ting, David T.
Greenbaum, Benjamin D.
author_facet Levine, Arnold J.
Ting, David T.
Greenbaum, Benjamin D.
author_sort Levine, Arnold J.
collection PubMed
description The recent publication by Wylie et al. is reviewed, demonstrating that the p53 protein regulates the movement of transposons. While this work presents genetic evidence for a piRNA‐mediated p53 interaction with transposons in Drosophila and zebrafish, it is herein placed in the context of a decade or so of additional work that demonstrated a role for p53 in regulating transposons and other repetitive elements. The line of thought in those studies began with the observation that transposons damage DNA and p53 regulates DNA damage. The presence of transposon movement can increase the rate of evolution in the germ line and alter genes involved in signal transduction pathways. Transposition can also play an important role in cancers where the p53 gene function is often mutated. This is particularly interesting as recent work has shown that de‐repression of repetitive elements in cancer has important consequences for the immune system and tumor microenvironment.
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spelling pubmed-50311992016-10-03 P53 and the defenses against genome instability caused by transposons and repetitive elements Levine, Arnold J. Ting, David T. Greenbaum, Benjamin D. Bioessays Prospects & Overviews The recent publication by Wylie et al. is reviewed, demonstrating that the p53 protein regulates the movement of transposons. While this work presents genetic evidence for a piRNA‐mediated p53 interaction with transposons in Drosophila and zebrafish, it is herein placed in the context of a decade or so of additional work that demonstrated a role for p53 in regulating transposons and other repetitive elements. The line of thought in those studies began with the observation that transposons damage DNA and p53 regulates DNA damage. The presence of transposon movement can increase the rate of evolution in the germ line and alter genes involved in signal transduction pathways. Transposition can also play an important role in cancers where the p53 gene function is often mutated. This is particularly interesting as recent work has shown that de‐repression of repetitive elements in cancer has important consequences for the immune system and tumor microenvironment. John Wiley and Sons Inc. 2016-05-13 2016-06 /pmc/articles/PMC5031199/ /pubmed/27172878 http://dx.doi.org/10.1002/bies.201600031 Text en 2016 The Authors BioEssays Published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Prospects & Overviews
Levine, Arnold J.
Ting, David T.
Greenbaum, Benjamin D.
P53 and the defenses against genome instability caused by transposons and repetitive elements
title P53 and the defenses against genome instability caused by transposons and repetitive elements
title_full P53 and the defenses against genome instability caused by transposons and repetitive elements
title_fullStr P53 and the defenses against genome instability caused by transposons and repetitive elements
title_full_unstemmed P53 and the defenses against genome instability caused by transposons and repetitive elements
title_short P53 and the defenses against genome instability caused by transposons and repetitive elements
title_sort p53 and the defenses against genome instability caused by transposons and repetitive elements
topic Prospects & Overviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031199/
https://www.ncbi.nlm.nih.gov/pubmed/27172878
http://dx.doi.org/10.1002/bies.201600031
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