Quantitative definition and monitoring of the host cell protein proteome using iTRAQ – a study of an industrial mAb producing CHO‐S cell line

There are few studies defining CHO host cell proteins (HCPs) and the flux of these throughout a downstream purification process. Here we have applied quantitative iTRAQ proteomics to follow the HCP profile of an antibody (mAb) producing CHO‐S cell line throughout a standard downstream purification p...

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Detalles Bibliográficos
Autores principales: Chiverton, Lesley M., Evans, Caroline, Pandhal, Jagroop, Landels, Andrew R., Rees, Byron J., Levison, Peter R., Wright, Phillip C., Smales, C. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031201/
https://www.ncbi.nlm.nih.gov/pubmed/27214759
http://dx.doi.org/10.1002/biot.201500550

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