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An explorative study of school performance and antipsychotic medication

BACKGROUND: Antipsychotic therapy can reduce severe symptoms of psychiatric disorders, however, data on school performance among children on such treatment are lacking. The objective was to explore school performance among children using antipsychotic drugs at the end of primary education. METHODS:...

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Autores principales: van der Schans, J., Vardar, S., Çiçek, R., Bos, H. J., Hoekstra, P. J., de Vries, T. W., Hak, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031249/
https://www.ncbi.nlm.nih.gov/pubmed/27655329
http://dx.doi.org/10.1186/s12888-016-1041-0
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author van der Schans, J.
Vardar, S.
Çiçek, R.
Bos, H. J.
Hoekstra, P. J.
de Vries, T. W.
Hak, E.
author_facet van der Schans, J.
Vardar, S.
Çiçek, R.
Bos, H. J.
Hoekstra, P. J.
de Vries, T. W.
Hak, E.
author_sort van der Schans, J.
collection PubMed
description BACKGROUND: Antipsychotic therapy can reduce severe symptoms of psychiatric disorders, however, data on school performance among children on such treatment are lacking. The objective was to explore school performance among children using antipsychotic drugs at the end of primary education. METHODS: A cross-sectional study was conducted using the University Groningen pharmacy database linked to academic achievement scores at the end of primary school (Dutch Cito-test) obtained from Statistics Netherlands. Mean Cito-test scores and standard deviations were obtained for children on antipsychotic therapy and reference children, and statistically compared using analyses of covariance. In addition, differences in subgroups as boys versus girls, ethnicity, household income, and late starters (start date within 12 months of the Cito-test) versus early starters (start date > 12 months before the Cito-test) were tested. RESULTS: In all, data from 7994 children could be linked to Cito-test scores. At the time of the Cito-test, 45 (0.6 %) were on treatment with antipsychotics. Children using antipsychotics scored on average 3.6 points lower than the reference peer group (534.5 ± 9.5). Scores were different across gender and levels of household income (p < 0.05). Scores of early starters were significantly higher than starters within 12 months (533.7 ± 1.7 vs. 524.1 ± 2.6). CONCLUSION: This first exploration showed that children on antipsychotic treatment have lower school performance compared to the reference peer group at the end of primary school. This was most noticeable for girls, but early starters were less affected than later starters. Due to the observational cross-sectional nature of this study, no causality can be inferred, but the results indicate that school performance should be closely monitored and causes of underperformance despite treatment warrants more research.
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spelling pubmed-50312492016-09-29 An explorative study of school performance and antipsychotic medication van der Schans, J. Vardar, S. Çiçek, R. Bos, H. J. Hoekstra, P. J. de Vries, T. W. Hak, E. BMC Psychiatry Research Article BACKGROUND: Antipsychotic therapy can reduce severe symptoms of psychiatric disorders, however, data on school performance among children on such treatment are lacking. The objective was to explore school performance among children using antipsychotic drugs at the end of primary education. METHODS: A cross-sectional study was conducted using the University Groningen pharmacy database linked to academic achievement scores at the end of primary school (Dutch Cito-test) obtained from Statistics Netherlands. Mean Cito-test scores and standard deviations were obtained for children on antipsychotic therapy and reference children, and statistically compared using analyses of covariance. In addition, differences in subgroups as boys versus girls, ethnicity, household income, and late starters (start date within 12 months of the Cito-test) versus early starters (start date > 12 months before the Cito-test) were tested. RESULTS: In all, data from 7994 children could be linked to Cito-test scores. At the time of the Cito-test, 45 (0.6 %) were on treatment with antipsychotics. Children using antipsychotics scored on average 3.6 points lower than the reference peer group (534.5 ± 9.5). Scores were different across gender and levels of household income (p < 0.05). Scores of early starters were significantly higher than starters within 12 months (533.7 ± 1.7 vs. 524.1 ± 2.6). CONCLUSION: This first exploration showed that children on antipsychotic treatment have lower school performance compared to the reference peer group at the end of primary school. This was most noticeable for girls, but early starters were less affected than later starters. Due to the observational cross-sectional nature of this study, no causality can be inferred, but the results indicate that school performance should be closely monitored and causes of underperformance despite treatment warrants more research. BioMed Central 2016-09-21 /pmc/articles/PMC5031249/ /pubmed/27655329 http://dx.doi.org/10.1186/s12888-016-1041-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
van der Schans, J.
Vardar, S.
Çiçek, R.
Bos, H. J.
Hoekstra, P. J.
de Vries, T. W.
Hak, E.
An explorative study of school performance and antipsychotic medication
title An explorative study of school performance and antipsychotic medication
title_full An explorative study of school performance and antipsychotic medication
title_fullStr An explorative study of school performance and antipsychotic medication
title_full_unstemmed An explorative study of school performance and antipsychotic medication
title_short An explorative study of school performance and antipsychotic medication
title_sort explorative study of school performance and antipsychotic medication
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031249/
https://www.ncbi.nlm.nih.gov/pubmed/27655329
http://dx.doi.org/10.1186/s12888-016-1041-0
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